8-hydroxy-3-methyl-3,4-dihydro-2H-benzo[a]anthracene-1,7,12-trione;3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 角环素
• 英文名称: 8-hydroxy-3-methyl-3,4-dihydro-2H-benzo[a]anthracene-1,7,12-trione;3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one
• 化学式: C34H24O10
• 分子量: 592.5
• InChiKey: CPNNXWGHZBBXFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.22
• 重原子数：
  44
• 可旋转键数：
  1
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  179
• 氢给体数：
  5
• 氢受体数：
  10

文献信息

• TH17 DIFFERENTIATION MARKERS FOR ACNE AND USES THEREOF
  申请人：Carlavan Isabelle

  公开号：US20140235475A1

  公开（公告）日：2014-08-21

  A method is described for using ROR gamma t or ROR alpha to diagnose acne and/or to screen inhibitors of Th17 differentiation. Specifically described are methods of inhibiting ROR gamma t or ROR alpha and use of the screened inhibitors in acne treatment.