申请人:Tokumaru Yoshihisa
公开号:US20060281917A1
公开(公告)日:2006-12-14
A process for preparing a penicillanic acid compound of the formula (2) comprising reacting a halogenated penicillanic acid compound of the formula (1), (a) in the presence of a metal bismuth or bismuth compound, (b) with a metal having a lower standard oxidation-reduction potential than bismuth to obtain the compound (2)
(X and Y are a hydrogen atom or halogen atom, provided that X and Y are not hydrogen atoms at the same time, n is an integer of 0 to 2, R is carboxylic acid protecting group)
(n and R are same as above).
一种制备式(2)青霉烷酸化合物的方法,包括在金属铋或铋化合物的存在下,将式(1)的卤代青霉烷酸化合物与比铋标准氧化还原电位低的金属反应,以获得化合物(2)(其中X和Y是氢原子或卤素原子,但不能同时为氢原子,n为0到2的整数,R为羧酸保护基)(n和R同上)。