NCX 4023 | 302606-04-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: NCX 4023
• 英文别名: Benzoic acid, 2-hydroxy-, 3-[(nitrooxy)methyl]phenyl ester；[3-(nitrooxymethyl)phenyl] 2-hydroxybenzoate
• CAS: 302606-04-8
• 化学式: C₁₄H₁₁NO₆
• 分子量: 289.244
• InChiKey: MKYGMVOKULQJBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Nitroderivatives as drugs for diseases having an inflammatory basis
  申请人：——

  公开号：US20040023933A1

  公开（公告）日：2004-02-05

  Use for the treatment of diseases having an inflammatory basis of compounds or salts thereof, having the following general formula (I): A-X t -L-(W) p —NO 2 wherein A contains the radical of a drug, X t and W arc bivalent radicals, L, is a covalent bond or oxygen, sulphur, NR tc wherein R tc is H or a C 1 -C 5 linear or branched alkyl.

  用于治疗具有炎症基础的疾病的化合物或其盐，具有以下一般公式（I）：A-X t -L-(W) p —NO 2 其中A含有药物的自由基，X t 和W是二价基团，L是共价键或氧、硫、NR tc ，其中R tc 是H或C 1 -C 5 的直链或支链烷基。
• [EN] NITRODERIVATIVES AS DRUGS FOR DISEASES HAVING AN INFLAMMATORY BASIS<br/>[FR] NITRODERIVES UTILES EN TANT QUE MEDICAMENTS DESTINES A DES MALADIES D'ORIGINE INFLAMMATOIRE
  申请人：NICOX SA

  公开号：WO2002030866A1

  公开（公告）日：2002-04-18

  Use for the treatment of diseases having an inflammatory basis of compounds or salts thereof, having the following general formula (I): A-X1-L-(W)p-NO2 wherein A contains the radical of a drug, X1 and W are bivalent radicals, L is a covalent bond or oxygen, sulphur, NR1c wherein R1c is H or a C1-C5 linear or branched alkyl.

  用于治疗具有炎症基础的疾病的化合物或其盐，其具有以下一般式（I）：A-X1-L-(W)p-NO2，其中A包含药物的基团，X1和W是二价基团，L是共价键或氧，硫，NR1c，其中R1c是H或C1-C5线性或支链烷基。
• Nitric oxide donor compounds
  申请人：——

  公开号：US20020032232A1

  公开（公告）日：2002-03-14

  Nitric oxide donor compounds of the formula: 1 are provided. In the formula, R is (CH 2 ) n , wherein n ranges from 1 to 8 and wherein each hydrogen atom on the alkylene group and on the phenyl groups can optionally be replaced by a substituent selected from the group consisting of alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, and hydroxy groups. A particularly preferred compound is 1,3-(nitrooxymethyl)phenyl 2-hydroxybenzoate. The compounds are useful for treating and preventing various conditions, including coronary artery disease.

  提供了公式为1的一氧化氮供体化合物。在公式中，R是(CH2)n，其中n的范围为1到8，其中烷基和苯基上的每个氢原子可以选择性地被取代为来自包括烷基、环烷基、杂环烷基、芳基、杂芳基、卤素和羟基基团的取代基。特别优选的化合物是1,3-(硝基氧甲基)苯基2-羟基苯甲酸酯。这些化合物可用于治疗和预防各种疾病，包括冠状动脉疾病。
• NITRODERIVATIVES AS DRUGS FOR DISEASES HAVING AN INFLAMMATORY BASIS
  申请人：DEL SOLDATO Piero

  公开号：US20080194651A1

  公开（公告）日：2008-08-14

  Use for the treatment of diseases having an inflammatory basis of compounds or salts thereof, Having the following general formula (I): A-X 1 -L-(W) p —NO 2 wherein A contains the radical of a drug, X 1 and W are bivalent radicals, L is a covalent bond or oxygen, sulphur, NR 1e wherein R 1e is H or a C 1 -C 5 linear or branched alkyl.

  用于治疗具有炎症基础的疾病的化合物或其盐，其具有以下通式（I）：A-X1-L-(W)p—NO2，其中A包含药物的基团，X1和W是双价基团，L是共价键或氧，硫，NR1，其中R1是H或C1-C5线性或支链烷基。
• NITRODERVIATIVES AS DRUGS FOR DISEASES HAVING AN INFLAMMATORY BASIS
  申请人：DEL SOLDATO Piero

  公开号：US20090075952A1

  公开（公告）日：2009-03-19

  Use for the treatment of diseases having an inflammatory basis of compounds or salts thereof, having the following general formula (I): A-X 1 -L-(W) p -NO 2 wherein A contains the radical of a drug, X 1 and W are bivalent radicals, L is a covalent bond or oxygen, sulphur, NR 1c wherein R 1c is H or a C 1 -C 5 linear or branched alkyl.

  用于治疗具有炎症基础的疾病的化合物或其盐，其具有以下一般式（I）：A-X1-L-（W）p-NO2，其中A包含药物的基团，X1和W是二价基团，L是共价键或氧，硫，NR1c，其中R1c是H或C1-C5线性或支链烷基。