Strontium;dinitrate

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱土金属氧阴离子化合物
• 英文名称: Strontium;dinitrate
• 化学式: N2O6Sr
• 分子量: 211.63
• InChiKey: DHEQXMRUPNDRPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.86
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  126
• 氢给体数：
  0
• 氢受体数：
  6

ADMET

代谢

硝酸盐通常在消化道内转化为亚硝酸盐。亚硝酸盐是在绵羊和牛的瘤胃中硝酸盐还原为氨的中间产物... /硝酸盐和亚硝酸盐/

TRANSFORMATION OF NITRATE TO NITRITE USUALLY OCCURS WITHIN ALIMENTARY TRACT. NITRITE IS AN INTERMEDIARY PRODUCT IN REDUCTION OF NITRATE TO AMMONIA WITHIN THE RUMEN OF SHEEP & COW ... /NITRATES & NITRITES/

来源:Hazardous Substances Data Bank (HSDB)

代谢

摄入一定量的硝酸盐和亚硝酸盐是人类氮循环的正常部分。在适当条件下，硝酸盐可以在胃肠道内转化为亚硝酸盐，显著增加硝酸盐的毒性。硝酸盐的主要代谢途径是转化为亚硝酸盐，然后转化为氨。亚硝酸盐、硝酸盐及其代谢物通过尿液排出体外。

Intake of some amount of nitrates and nitrites is a normal part of the nitrogen cycle in humans. In vivo conversion of nitrates to nitrites can occur in the gastrointestional tract under the right conditions, significantly enhancing nitrates' toxic potency. The major metabolic pathway for nitrate is conversion to nitrite, and then to ammonia. Nitrites, nitrates, and their metabolites are excreted in the urine. (L1137)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

硝酸盐的毒性是由于它进入体内后转化为亚硝酸盐。亚硝酸盐会导致氧合血红蛋白的自动催化氧化，生成过氧化氢和高铁血红蛋白。高铁血红蛋白水平的升高是一种称为高铁血红蛋白血症的状况，其特点是组织缺氧，因为高铁血红蛋白无法结合氧气。

Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

摄入硝酸盐或亚硝酸盐，在导致内源性亚硝化的条件下，对人类可能是致癌的（2A组）。

Ingested nitrate or nitrite under conditions that result in endogenous nitrosation is probably carcinogenic to humans (Group 2A). (L135)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

硝酸盐和亚硝酸盐中毒会导致高铁血红蛋白血症。亚硝酸盐可能会导致怀孕并发症和发育影响。它们也可能具有致癌性。

Nitrate and nitrite poisoning causes methemoglobinemia. Nitrites may cause pregnancy complications and developmental effects. They may also be carcinogenic. (L1137)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

口服（L1137）；吸入（L1137）

Oral (L1137) ; inhalation (L1137)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

硝酸盐和亚硝酸盐中毒导致高铁血红蛋白血症。症状包括发绀、心脏心律不齐和循环衰竭，以及逐渐加重的中枢神经系统（CNS）影响。中枢神经系统的影响可能从轻微的眩晕和嗜睡到昏迷和抽搐不等。

Nitrate and nitrite poisoning causes methemoglobinemia. Symptoms include cyanosis, cardiac dysrhythmias and circulatory failure, and progressive central nervous system (CNS) effects. CNS effects can range from mild dizziness and lethargy to coma and convulsions. (L1137)

来源:Toxin and Toxin Target Database (T3DB)

吸收、分配和排泄

锶-89与硝酸锶溶液污染的积累与分布已在四周大的猪体内确定。锶在皮肤中积累，但以显著数量渗透得更深。

THE ACCUMULATION & DISTRIBUTION OF (89)STRONTIUM CONTAMINATED WITH STRONTIUM NITRATE SOLUTION WERE DETERMINED IN 4 WK-OLD PIGS. STRONTIUM ACCUMULATES IN SKIN BUT PENETRATES MUCH DEEPER IN NOTICEABLE QUANTITY.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

口服硝酸锶在大鼠骨骼中的积累与剂量成正比，这一结果是在4周和8周的喂养实验中确定的。骨骼储存平均为剂量的2.7%，这一百分比不受性别、年龄或从30-1030 ppm硝酸锶的喂养水平的影响。在口服硝酸锶之前，幼年（6周）大鼠的骨灰中锶含量为7.7 ppm；成年大鼠为11.8 ppm。骨保留因子（锶原子数/1000钙原子数除以饮食中同一比例）平均为0.20，表明相较于锶，钙的保留更为优先。

ORALLY ADMIN STRONTIUM NITRATE ACCUMULATED IN SKELETON OF RATS IN PROPORTION TO DOSE, AS DETERMINED IN 4- & 8-WK FEEDING TESTS. SKELETAL STORAGE AVERAGED 2.7% OF DOSE, & THE PERCENTAGE WAS UNINFLUENCED BY SEX OR AGE OR BY LEVEL FED FROM 30-1030 PPM STRONTIUM NITRATE. YOUNG (6-WK) RATS HAD 7.7 PPM STRONTIUM IN BONE ASH BEFORE ADMIN OF STRONTIUM; ADULTS HAD 11.8 PPM. THE BONE RETENTION FACTOR ... (NUMBER OF SR ATOMS/1000 CALCIUM ATOMS DIVIDED BY THE SAME RATIO FOR THE DIET), AVERAGED 0.20, INDICATING A PREFERENTIAL RETENTION OF CALCIUM TO THAT OF STRONTIUM.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

骶髂关节和脊柱的步进式扫描放射性核素显像在已确诊或疑似强直性脊柱炎的患者中进行，这些患者在注射85锶硝酸盐（85）的100微居里后2周进行了检查。在骶髂关节早期X光改变且脊柱受累最小的病例中，85锶的摄取量较高。

STEP-SCAN SCINTIMETRY OF THE SACROILIAC JOINTS AND SPINE WAS PERFORMED IN PATIENTS WITH ESTABLISHED OR SUSPECTED ANKYLOSING SPONDYLITIS 2 WEEKS AFTER INJECTION OF 100 MICROCURIES OF RADIOACTIVE STRONTIUM NITRATE (85). STRONTIUM UPTAKE OF (85) STRONTIUM WAS HIGH IN CASES WITH EARLY ROENTGENOGRAPHIC CHANGES OF THE SACROILIAC JOINTS AND MINIMAL SPINAL INVOLVEMENT.

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  Strontium;dinitrate 生成 超细氧化锶
  参考文献：
  名称：

  GRESKOVICH, CHARLES D.;OCLAIR, CHESTER R.

  摘要：

  DOI：
• 作为产物：
  描述：

  硝酸 生成 Strontium;dinitrate
  参考文献：
  名称：

  BELOKOSKOV, V. I.;SMIRNOVA, I. P.;POPOVA, L. A.;LEBEDEV, V. N.;SERKOVA, R+

  摘要：

  DOI：
• 作为试剂：
  描述：

  strontium(II) carbonate 、 硝酸 在 Strontium;dinitrate 作用下， 以yielding strontium nitrate tetrahydrate (Sr(NO3)2.4H2O)的产率得到Strontium nitrate tetrahydrate
  参考文献：
  名称：

  Strontium nitrate and method for manufacturing same

  摘要：

  提供低成本、高纯度的硝酸锶，其中含有低量的钡、钠、钙、铬和其他杂质，适用于气囊等用途。通过制造方法生产高纯度的硝酸锶，其钡含量低于0.01重量％，钠含量低于0.005重量％，钙含量低于0.01重量％，铬含量小于0.001重量％，纯度为99.5重量％或更高。该制造方法包括第一步，通过向溶解锶化合物的水溶液中加入硝酸进行结晶，第二步，分离所得的晶体，第三步，结晶所得的分离溶液，第四步，分离所得的晶体。

  公开号：

  US06221322B1

文献信息

• Preparation of strontium carbonate
  申请人：FMC Corporation

  公开号：US04421729A1

  公开（公告）日：1983-12-20

  Strontium carbonate is prepared by the process of reacting strontium nitrate in an aqueous reaction medium with carbon dioxide to precipitate strontium carbonate product, the nitric acid byproduct that forms being neutralized by the introduction of lime to the reaction medium.

  碳酸锶是通过在水溶液反应介质中将硝酸锶与二氧化碳反应以沉淀出碳酸锶产品的过程制备的，生成的硝酸副产物通过向反应介质中引入石灰来中和。
• Method of forming patterned oxide superconducting films
  申请人：AMP Incorporated

  公开号：US05021398A1

  公开（公告）日：1991-06-04

  The present invention describes a method to produce a patterned superconducting solid preferably as a thin film. Unsaturated organic acid metal salts of suitable metals are dissolved in an organic solvent, mixed thoroughly and cast as a film on a substrate. The concentration of these organic carboxylate metal salts is adjusted such that a superconducting metal oxide ratio is obtained upon pyrolysis at temperatures up to 1000.degree. C. with subsequent slow cooling. A pattern (mask) is placed over the film and the film is irradiated to polymerize and crosslink the exposed portions. The unpolymerized and uncrosslinked portions are removed usually by using selective solvents or solvent mixtures. The solid remaining is heated in oxygen or air to about 1000.degree. C., which removes the organic portions and leaves metal oxide residue. The metal oxides are then cooled slowly and annealed to produce the patterned metal oxide superconducting materials. The articles of manufacture produced are useful in fabricating devices requiring superconducting thin films in addition to other uses.

  本发明描述了一种制备图案超导固体的方法，最好是作为薄膜。将合适金属的不饱和有机酸金属盐溶解在有机溶剂中，充分混合并铸成薄膜放在基板上。调整这些有机羧酸金属盐的浓度，使在高达1000°C的热解过程中获得超导金属氧化物比例，随后缓慢冷却。将图案（掩膜）放在薄膜上，并照射薄膜以使暴露部分聚合和交联。通常使用选择性溶剂或溶剂混合物去除未聚合和未交联的部分。剩余的固体在氧气或空气中加热到约1000°C，这将去除有机部分并留下金属氧化物残留物。然后缓慢冷却和退火以产生图案的金属氧化物超导材料。制造出的制品在制造需要超导薄膜的设备以及其他用途方面非常有用。
• Polyester polymerization catalyst, polyester produced by using the same, and process for producing polyester
  申请人：——

  公开号：US20030083191A1

  公开（公告）日：2003-05-01

  This invention provides a novel polymerization catalyst other than antimony compounds, polyester produced by using the same and a process for producing polyester. The polycondensation catalyst of this invention is a polyester polymerization catalyst comprising an aluminum compound and a phosphorus compound having a specific structure. Further, this invention relates to polyester produced by using this polyester polymerization catalyst and a process for producing polyester. Further, this invention relates to fibers, films and hollow molded articles mprising the polyester.

  本发明提供了一种新型聚合催化剂，除了锑化合物外，还提供了由该催化剂制备的聚酯以及制备聚酯的方法。本发明的聚酯缩聚催化剂是一种聚酯聚合催化剂，包括一种铝化合物和一种具有特定结构的磷化合物。此外，本发明还涉及使用该聚酯聚合催化剂制备的聚酯和制备聚酯的方法。此外，本发明还涉及由该聚酯制备的纤维、薄膜和空心成型制品。
• Preparation of strontium nitrate from celestite and calcium nitrate
  申请人：FMC Corporation

  公开号：US04337233A1

  公开（公告）日：1982-06-29

  Strontium nitrate is prepared by reacting celestite (strontium sulfate) with excess calcium nitrate in limited amounts of water, quickly extracting strontium nitrate from the reaction mixture by vigorous agitation with additional water, and recovering strontium nitrate by evaporation of the extract solution.

  硝酸锶是通过将天青石（硫酸锶）与过量的硝酸钙在少量水中反应制备的，通过用额外的水强烈搅拌迅速从反应混合物中提取硝酸锶，并通过蒸发提取溶液来回收硝酸锶。
• Method of making metal oxide ceramic powders by using a combustible
  申请人：Battelle Memorial Institute

  公开号：US05114702A1

  公开（公告）日：1992-05-19

  This invention is directed to the formation of homogeneous, aqueous precursor mixtures of at least one substantially soluble metal salt and a substantially soluble, combustible co-reactant compound, typically an amino acid. This produces, upon evaporation, a substantially homogeneous intermediate material having a total solids level which would support combustion. The homogeneous intermediate material essentially comprises highly dispersed or solvated metal constituents and the co-reactant compound. The intermediate material is quite flammable. A metal oxide powder results on ignition of the intermediate product which combusts same to produce the product powder.

  本发明旨在形成至少一种基本可溶的金属盐和一种基本可溶的可燃共反应化合物（通常是氨基酸）的均质水性前体混合物。这样，在蒸发后，就会产生一种具有可燃性的总固体水平的基本均质中间物。均质中间物基本上由高度分散或溶解的金属成分和共反应剂化合物组成。中间物是相当易燃的。在点燃中间产物时，会产生金属氧化物粉末，其燃烧产生产品粉末。