Spermine phosphate | 2779-91-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Spermine phosphate
• 英文别名: 4,9-diazadodecane-1,12-diamine phosphate；N,N'-Bis(3-aminopropyl)butan-1,4-diamine phosphate；N,N'-bis(3-aminopropyl)butane-1,4-diamine;phosphoric acid
• CAS: 2779-91-1
• 化学式: C₁₀H₂₆N₄*H₃O₄P
• 分子量: 300.338
• InChiKey: JTUDXELSEBMWLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.29
• 重原子数：
  19
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  154
• 氢给体数：
  7
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  potassium tetrachloroplatinate(II) 、 Spermine phosphate 在 NaCl 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 铂(2+)氯化N,N'-二(3-氨基丙基)丁烷-1,4-二胺(2:4:1)
  参考文献：
  名称：

  Dichloro(propane-1,3-diamine-κ²N,N′)platinum(II), dichloro(propane-1,3-diamine-κ²N,N′)palladium(II) and μ-4,9-diazadodecane-1,12-diamine-κ²N¹,N⁴:κ²N⁹,N¹²-bis[dichloroplatinum(II)]

  摘要：

  In the title compounds, [PtCl2(C3H10N2)], (I), [PdCl2(C3H10N2)], (II), and [Pt2Cl4(C10H26N4)], (III), each metal atom lies in a distorted cis-square coordination geometry. Compounds (I) and (II) are isostructural, and each complex has a mirror plane through the metal atom and the middle C atom of the propane-1,3-diamine ligand. In (III), the binuclear Complex [Pt2Cl4(spn)] has an inversion center at the middle of the 4,9-diazadodecane-1,12-diamine (spermine, spn) ligand. The six-membered chelate rings in (III) adopt a chair form, which is unsymmetrical and less flattened than those in (I) and (II). In all three crystal structures, there are intermolecular N-H center dot center dot center dot Cl hydrogen bonds.

  DOI：

  10.1107/s010827010600610x

文献信息

• Use of cross-protection to identify novel vaccine candidates for infectious agents
  申请人：——

  公开号：US20040151736A1

  公开（公告）日：2004-08-05

  This invention discloses methods for identifying Francisella tularensis vaccine candidates. It enables identification of novel vaccine candidates and quality assurance for vaccine batches, assessment of protection in vaccinates and identification of the infecting agent in vaccinates. Mice were first vaccinated with Brucella abortus O-polysaccharide (OPS) vaccine. These animals were then given 10 LD 50 s of F. tularensis live vaccine strain (LVS). Sixty percent (60%) of the vaccinated mice survived the multiple lethal doses. Sera were collected from these surviving mice and the antibodies were used to probe supernatant and cell lysates of live F. tularensis LVS cultures. Several F. tularensis components were identified only by the noted “survivor” antisera. Of these identified proteins, enzyme digestions and chemical oxidation suggest post-translational modifications of some proteins e.g. a 52 kDa glycoprotein, a 45 kDa lipoprotein and a 19 kDa nucleoprotein. The 52 kDa component caused nitrous oxide induction in tissue cultures at low concentrations, cell death at high concentrations. Vaccination with this gave partial protection while addition of other components acted synergistically to give enhanced protection from 250 LD 50 s of F. tularensis LVS.

  本发明公开了用于鉴定 土拉弗氏菌 候选疫苗的方法。通过该方法可以鉴定新型候选疫苗，保证疫苗批次的质量，评估疫苗的保护作用，鉴定疫苗的感染源。首先用 流产布鲁氏菌 O-多糖（OPS）疫苗。然后给这些动物注射 10 LD 50 的 土拉菌 活疫苗菌株（LVS）。60%的接种小鼠在多次致死剂量后存活下来。从这些存活的小鼠身上收集血清，用抗体探查活的 F. tularensis LVS 培养物。几种 土拉菌 只有 "幸存者 "抗血清能鉴定出其中的几种成分。在这些已鉴定的蛋白质中，酶消化和化学氧化表明一些蛋白质发生了翻译后修饰，如 52 kDa 糖蛋白、45 kDa 脂蛋白和 19 kDa 核蛋白。52 kDa 成分在低浓度下会在组织培养物中引起一氧化二氮，在高浓度下会导致细胞死亡。接种该成分的疫苗可提供部分保护，而添加其他成分则可发挥协同作用，在 250 LD 50 s 的 F. tularensis LVS。
• US4591605A
  申请人：——

  公开号：US4591605A

  公开（公告）日：1986-05-27
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  申请人：——

  公开号：US5514569A

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  申请人：——

  公开号：US7323180B2

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  申请人：——

  公开号：US7579182B2

  公开（公告）日：2009-08-25