Actinium-227 | 14952-40-0

• 分子结构分类: 无机化合物 - 均相金属化合物 - 均相锕系化合物
• 英文名称: Actinium-227
• CAS: 14952-40-0
• 化学式: Ac
• 分子量: 227.02775
• InChiKey: QQINRWTZWGJFDB-IGMARMGPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.0
• 重原子数：
  1
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

ADMET

毒理性

• 毒性总结

由锕产生的电离辐射导致的细胞损伤包括DNA断裂、准确或不准确的修复、细胞凋亡、基因突变、染色体改变和遗传不稳定性。这导致正常细胞和组织的稳态丧失，并发展为恶性肿瘤。不直接损伤DNA的电离辐射可以产生反应性氧中间体，这些中间体直接影响细胞周期调节中重要的酶p53的稳定性，并通过DNA复制期间的错配产生DNA单个碱基的氧化损伤和点突变。

The ionizing radiation produced by actinium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal change, and genetic instability. This leads to loss of normal cell and tissue homeostasis, and development of malignancy. Ionizing radiation that does not directly damage DNA can produce reactive oxygen intermediates that directly affect the stability of p53, an important enzyme in cell-cycle regulation, and produce oxidative damage to individual bases in DNA and point mutations by mispairing during DNA replication. (L1837)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

内化的发射α或β粒子的放射性核素对人类具有致癌性（第1组）（L2150）。镭-227经历α和β衰变。

Internalized radionuclides that emit α or β particles are carcinogenic to humans (Group 1) (L2150). Actinium-227 undergoes alpha and beta decay.

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

锕元素极具放射性，因此存在危险的癌症风险。它还可能引起急性辐射综合症。

Actinium is extremely radioactive and thus poses a dangerous cancer risk. It can also cause acute radiation syndrome. (L1131)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

口服（L1837）；吸入（L1837）

Oral (L1837) ; Inhalation (L1837)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

暴露在高剂量的电离辐射下会导致急性辐射综合症，可能会造成皮肤烧伤、脱发、恶心、呕吐、眩晕、定向障碍、低血压、头痛、疲劳、虚弱、发热、出生缺陷、疾病、感染甚至死亡。

Exposure to high doses of ionizing radiation results in acute radiation syndrome, which can cause skin burns, hair loss, nausea, vomiting, dizziness, disorientation, low blood pressure, headache, fatigue, weakness, fever, birth defects, illness, infection, and death. (L1837, L1852)

来源:Toxin and Toxin Target Database (T3DB)