8-Azabicyclo(3.2.1)octane, 3-methoxy-8-methyl-, endo- | 20411-17-0

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: 8-Azabicyclo(3.2.1)octane, 3-methoxy-8-methyl-, endo-
• 英文别名: 2-methoxy-8-methyl-8-azabicyclo[3.2.1]octane
• CAS: 20411-17-0
• 化学式: C₉H₁₇NO
• 分子量: 155.24
• InChiKey: LWXRLTQBGGVKIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Dialkylamino alkyl esters of pivagabine as medicaments for the treatment of central nervous system disorders
  申请人：Rafferty Michael

  公开号：US20090111813A1

  公开（公告）日：2009-04-30

  The present embodiments are related to the compound of Formula 1 or Formula 2 below and pharmaceutical formulations thereof as well as treatments for a wide variety of Central Nervous System disorders with the pharmaceutical formulations. Some embodiments include the use of a variety of the instant compounds which surprisingly and advantageously exhibit improved pharmacokinetic and therapeutic profiles in comparison to pivagabine.

  现有实施例与以下公式1或公式2的化合物及其制药配方以及使用制药配方治疗各种中枢神经系统疾病有关。一些实施例包括使用各种即时化合物，这些化合物与哌加宾相比出人意料地展示出改善的药代动力学和治疗特征。
• DIALKYLAMINO ALKYL ESTERS OF PIVAGABINE AS MEDICAMENTS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS
  申请人：Rafferty Michael

  公开号：US20100099678A1

  公开（公告）日：2010-04-22

  The present embodiments are related to the compound of Formula 1 or Formula 2 below and pharmaceutical formulations thereof as well as treatments for a wide variety of Central Nervous System disorders with the pharmaceutical formulations. Some embodiments include the use of a variety of the instant compounds which surprisingly and advantageously exhibit improved pharmacokinetic and therapeutic profiles in comparison to pivagabine.

  本实施例涉及以下公式1或公式2的化合物及其制药配方，以及使用该制药配方治疗各种中枢神经系统疾病。一些实施例包括使用各种瞬时化合物，这些化合物与哌加宾相比，出人意料地表现出改善的药代动力学和治疗特性的优点。
• US7632836B2
  申请人：——

  公开号：US7632836B2

  公开（公告）日：2009-12-15
• US8080548B2
  申请人：——

  公开号：US8080548B2

  公开（公告）日：2011-12-20