butyl benzyl phthalate | 38411-12-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: butyl benzyl phthalate
• 英文别名: Phthalic acid, butyl phenyl ester；1-O-butyl 2-O-phenyl benzene-1,2-dicarboxylate
• CAS: 38411-12-0
• 化学式: C₁₈H₁₈O₄
• 分子量: 298.339
• InChiKey: ZXEWECPOIXUDES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Filler containing hardenable resin products
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0169639A1

  公开（公告）日：1986-01-29

  A coarse/fine particulate inert solid filler component, e.g., limestone and/or sand, is used in a hardenable resin composition adapted for use in making set products, e.g., a hardened grout for anchoring a reinforcing member in a hole. About from 5 to 50 percent by weight of the filler is a coarse filler component comprised of particles in a size range whose minimum is about 1 mm, or a size range which is from 30 to 150 percent of the thickness of the annular layer of hardened grout formed around a reinforcing member. The thus-filled resin composition is readily miscible and flowable even at total filler levels as high as about 88 percent by weight. Rock bolt grouting products containing this resin composition require less bolt spinning and afford improved anchorage strength, even when used to point anchor mechanical expansion shells.

  粗/细颗粒惰性固体填料成分，如石灰石和/或砂，用于可硬化树脂组合物中，该树脂组合物可用于制造固化产品，如用于在孔中锚固加固部件的硬化灌浆料。按重量计，约 5%至 50%的填料是粗填料成分，由最小尺寸范围约为 1 毫米的颗粒组成，或其尺寸范围为在加固构件周围形成的硬化灌浆料环形层厚度的 30%至 150%。这样填充的树脂组合物即使在填充物总重量高达约 88% 的情况下也很容易混溶和流动。含有这种树脂成分的岩石螺栓灌浆产品所需的螺栓旋转次数更少，锚固强度更高，即使用于点锚机械膨胀螺栓时也是如此。
• Shaped articles of graduated refractive index exhibiting low dispersion
  申请人：HOECHST CELANESE CORPORATION

  公开号：EP0606598A2

  公开（公告）日：1994-07-20

  A monolithic, thermoplastic article with a continuously graded refractive index is formed by polymerizing a fluorinated matrix polymer in the presence of a low molecular weight, substantially unreactive guest molecule of different refractive index than the matrix polymer. The thermoplastic articles may be used to produce shaped articles such as optical waveguides, fibers or lenses of low attenuation and high bandwidth.

  一种具有连续分级折射率的整体热塑性制品，是通过聚合含氟基质聚合物，并在存在与基质聚合物折射率不同的低分子量、基本无反应的客体分子的情况下形成的。这种热塑性材料可用于生产低衰减、高带宽的异形材料，如光波导、光纤或透镜。
• METHOD FOR PREPARING MICROSPHERES FOR EMBOLI, AND METHOD FOR PREPARING MICROSPHERES TO WHICH DRUG-CONTAINING CARRIER IS BOUND
  申请人：Chung-Ang University Industry Academic Cooperation Foundation

  公开号：EP2891485A2

  公开（公告）日：2015-07-08

  A process for optimizing the recoverability of lyophilized microspheres for emboli and chitosan microspheres to which a drug-containing carrier is bound are disclosed. Specifically, a process for optimizing the recoverability, which includes adding trehalose as a lyophilization protectant prior to a lyophilization process for stable storage of the microspheres, and vortexing the lyophilized microspheres in order to rehydrate the microspheres, is provided. Also, microspheres capable of precisely controlling the release of the drug since the quantity of a drug released from the chitosan microspheres having a drug-containing nano-carrier bound thereto is adjusted according to the drug/chitosan ratio, and a method of preparing the same are provided. The optimization process can be useful in maintaining the physical properties, shapes, and the drug release level of the microspheres for emboli even after lyophilization of the microspheres. The chitosan microspheres having the drug-containing nano-carrier bound thereto can be useful in stably causing emboli in blood vessels, and precisely adjusting the release of the drug, and thus can be used in anticancer treatment.

  本发明公开了一种优化用于栓塞的冻干微球和结合了含药载体的壳聚糖微球的可回收性的工艺。具体地说，本发明提供了一种优化可回收性的工艺，其中包括在冻干工艺前添加曲哈洛糖作为冻干保护剂，以稳定储存微球，并对冻干微球进行涡旋以重新水化微球。此外，还提供了能够精确控制药物释放的微球，因为从结合了含药纳米载体的壳聚糖微球中释放的药物量可根据药物/壳聚糖的比例进行调整，还提供了制备这种微球的方法。该优化过程有助于保持微球的物理性质、形状和药物释放水平，即使在微球冻干后仍可用于栓塞。结合了含药纳米载体的壳聚糖微球可以稳定地在血管中形成栓子，并精确地调节药物的释放，因此可用于抗癌治疗。
• MICROBEADS FOR EMBOLIZATION AND COMPOSITION FOR TREATING PROLIFERATIVE DISEASES
  申请人：Plmicromed Co., Ltd.

  公开号：EP3954399A1

  公开（公告）日：2022-02-16

  The present disclosure provides a biocompatible polymer, and the polymer includes the embolic microbead including an iron adsorption block capable of adsorbing an iron component. The embolic microbead according to the an exemplary embodiment of the present disclosure adsorbs iron and thus effectively blocks an iron component delivered to cancer cells, and when used in embolization, it has an improved effect in treating cancers, such as liver cancer.

  本公开提供了一种生物相容性聚合物，该聚合物包括栓塞微珠，栓塞微珠包括能够吸附铁成分的铁吸附块。根据本公开的一个示例性实施例的栓塞微珠可吸附铁，从而有效阻断传递给癌细胞的铁成分，当用于栓塞时，它在治疗癌症（如肝癌）方面具有更好的效果。
• Organic grouting system for anchoring a bolt in a hole, and cartridge containing such composition
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0029677B1

  公开（公告）日：1983-03-30