Itasetron hydrochloride | 127618-28-4

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: Itasetron hydrochloride
• 英文别名: N-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-3H-benzimidazole-1-carboxamide;hydrochloride
• CAS: 127618-28-4
• 化学式: C16H21ClN4O2
• 分子量: 336.81
• InChiKey: WKDOOXQPGYZUKZ-YSEZWWCESA-N

物化性质

• 熔点：
  270°

计算性质

• 辛醇/水分配系数(LogP)：
  1.93
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  64.7
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Remedies for depression containing ep1 antagonist as the active ingredient
  申请人：——

  公开号：US20040082653A1

  公开（公告）日：2004-04-29

  A pharmaceutical composition for the treatment and/or prevention of depression comprising a compound having an antagonistic activity for EP 1 receptor which a prostaglandin E 2 receptor subtype. EP 1 antagonist is useful for the treatment of depression, for example, endogenous depression, reactive depression, weatherability depression, neurological depressed state, the depressed state of brain organic mental disorder.

  一种用于治疗和/或预防抑郁症的药物组合物，包括一种具有EP1受体拮抗活性的化合物，该受体是前列腺素E2受体亚型。EP1拮抗剂对于治疗抑郁症很有用，例如内源性抑郁症，反应性抑郁症，耐受性抑郁症，神经学抑郁状态，脑器质性心境障碍的抑郁状态。
• REMEDIES FOR DEPRESSION CONTAINING EP1 ANTAGONIST AS THE ACTIVE INGREDIENT
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1369129A1

  公开（公告）日：2003-12-10

  A pharmaceutical composition for the treatment and/or prevention of depression comprising a compound having an antagonistic activity for EP1 receptor which a prostaglandin E2 receptor subtype. EP1 antagonist is useful for the treatment of depression, for example, endogenous depression, reactive depression, weatherability depression, neurological depressed state, the depressed state of brain organic mental disorder.

  一种用于治疗和/或预防抑郁症的药物组合物，包含一种对前列腺素 E2 受体亚型的 EP1 受体具有拮抗活性的化合物。 EP1拮抗剂可用于治疗抑郁症，例如内源性抑郁症、反应性抑郁症、气候性抑郁症、神经性抑郁状态、脑器质性精神障碍的抑郁状态。
• Transdermal delivery system for anti-emetic medication
  申请人：Levin Galit

  公开号：US20050260252A1

  公开（公告）日：2005-11-24

  The present invention provides a transdermal delivery system for hydrophilic anti-emetic agents and methods of using thereof. The system includes an anti-emetic hydrophilic adhesive composition of a hydrophilic polymer and hydrophilic anti-emetic agent, a patch containing at least one hydrophilic layer of the composition, and an apparatus that generates hydrophilic micro-channels in skin of a subject using the patch or composition. The system preferably avoids the use of penetration enhancers and is particularly useful for transdermal delivery of hydrophilic anti-emetic agents.

  本发明提供了一种亲水性止吐剂透皮给药系统及其使用方法。该系统包括由亲水性聚合物和亲水性止吐剂组成的止吐亲水性粘合剂组合物、含有至少一层该组合物亲水层的贴片，以及在使用该贴片或组合物的受试者皮肤上产生亲水性微通道的装置。该系统最好避免使用渗透促进剂，尤其适用于亲水性止吐剂的透皮给药。
• TRANSDERMAL DELIVERY SYSTEM FOR ANTI-EMETIC MEDICATION
  申请人：Transpharma Medical Ltd.

  公开号：EP1556135A2

  公开（公告）日：2005-07-27
• US7335776B2
  申请人：——

  公开号：US7335776B2

  公开（公告）日：2008-02-26