Hexylphosphanone | 91108-24-6

• 分子结构分类: 有机化合物 - 有机磷化合物
• 英文名称: Hexylphosphanone
• 英文别名: 1-phosphorosohexane
• CAS: 91108-24-6
• 化学式: C₆H₁₃OP
• 分子量: 132.14
• InChiKey: COFGCRBLCTYHBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] LIGAND-MODIFIED DOUBLE-STRANDED NUCLEIC ACIDS<br/>[FR] ACIDES NUCLÉIQUES DOUBLE BRIN MODIFIÉS PAR UN LIGAND
  申请人：DICERNA PHARMACEUTICALS INC

  公开号：WO2016100401A1

  公开（公告）日：2016-06-23

  The invention provides for double stranded nucleic acid molecules comprising a 5 'extension of the sense or antisense strand and further comprising a plurality of nucleotides that are conjugated to a ligand and methods of using the double-stranded nucleic acid molecules. Ligand-modified oligomers where the sense stands form a tetraloop provide new potent and stable RNA interference agents. These dsNA molecules are synthesized using a plurality of nucleotides that include ligand-modified monomers, nucleotide analog monomers, modified nucleotide monomers and the like, using standard nucleotide synthetic methods and systems.

  该发明提供了包括具有感链或反义链的5'延伸以及进一步包括与配体结合的多个核苷酸的双链核酸分子，以及使用这些双链核酸分子的方法。其中，感链形成四环的配体修饰寡聚物提供了新的强效和稳定的RNA干扰剂。这些双链核酸分子是使用包括配体修饰单体、核苷酸类似物单体、修饰核苷酸单体等的多个核苷酸合成的，使用标准的核苷酸合成方法和系统。
• [EN] METHOD FOR PRODUCING HIGHER LINEAR FATTY ACIDS OR ESTERS<br/>[FR] PROCÉDÉ DE PRODUCTION D'ACIDES GRAS OU D'ESTERS LINÉAIRES SUPÉRIEURS
  申请人：EVONIK OPERATIONS GMBH

  公开号：WO2021233732A1

  公开（公告）日：2021-11-25

  The present invention relates to a method of producing linear fatty acids comprising 7 to 28 carbon atoms or esters thereof using a combined biotechnological and chemical method. In particular, the present invention relates to a method of producing dodecanoic acid (i.e. lauric acid), via higher alkanones, preferably 6-undecanone.

  本发明涉及一种利用结合生物技术和化学方法生产具有7至28个碳原子的直链脂肪酸或其酯的方法。具体来说，本发明涉及一种通过较高的烷酮，特别是6-十一酮，生产十二酸（即月桂酸）的方法。
• [EN] DI-ISOPROPYL-PHOSPHINOYL-ALKANE (DAPA) COMPOUNDS AS TOPICAL AGENTS FOR THE TREATMENT OF SENSORY DISCOMFORT<br/>[FR] COMPOSÉS DI-ISOPROPYL-PHOSPHINOYL-ALCANES (DAPA) EN TANT QU'AGENTS TOPIQUES POUR LE TRAITEMENT D'UNE GÊNE SENSORIELLE
  申请人：WEI EDWARD TAK

  公开号：WO2015059432A1

  公开（公告）日：2015-04-30

  The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain di-isopropyl-phosphinoyl- alkanes as described herein (DIPA-1-6, DIPA-1-7, DIPA-1-8, and DIPA-1-9, collectively referred to herein as "DIPA compounds") that are useful, for example, in the treatment of disorders (e.g., diseases) including: sensory discomfort (e.g., caused by irritation, itch, or pain); a skin dysesthesia; dermatitis; psoriasis; ocular discomfort; heat discomfort; heat stress; flushing and/or night sweats (vasomotor symptoms) in post-menopausal women; post-operative hypothermia; post-anaesthetic shivering; fatigue; tiredness; depression; cognitive dysfunction; and to enhance cognitive function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, for example, in therapy.

  本发明涉及治疗化合物领域。更具体地，本发明涉及如下所述的某些二异丙基氧代磷酰基烷烃（DIPA-1-6、DIPA-1-7、DIPA-1-8和DIPA-1-9，统称为“DIPA化合物”），例如在治疗以下疾病时有用：感觉不适（例如由刺激、瘙痒或疼痛引起）；皮肤失感；皮炎；牛皮癣；眼部不适；热不适；热应激；面部潮红和/或绝经后妇女的盗汗（血管运动症状）；术后低体温症；术后麻醉颤抖；疲劳；疲倦；抑郁；认知功能障碍；以及增强认知功能。本发明还涉及包含这种化合物的制药组合物，以及这种化合物和组合物的使用，例如在治疗中。
• Process for the preparation of halogenated hydrocarbons with at least 3 carbon atoms by reacting CFCl3 with an olefin
  申请人：SOLVAY (Société Anonyme)

  公开号：EP1908745A1

  公开（公告）日：2008-04-09

  A telomerisation process is described whereby fluorotrichloromethane is added to olefins like 2-chloroprop-1-ene, preferably in the presence of a catalyst. The reaction products, e.g. 1,1,3,3-tetrachloro-1-fluorobutane, can be further fluorinated.

  描述了一种端部延伸过程，其中氟三氯甲烷被添加到类似2-氯丙-1-烯的烯烃中，最好在催化剂的存在下进行。反应产物，例如1,1,3,3-四氯-1-氟丁烷，可以进一步氟化。
• [EN] 1-DI(SEC-BUTYL)-PHOSPHINOYL-PENTANE (DAPA-2-5) AS A TOPICAL AGENT FOR THE TREATMENT OF DISCOMFORT FROM NON-KERATINIZED STRATIFIED EPITHELIAL (NKSE) TISSUE<br/>[FR] 1-DI(SEC-BUTYL)-PHOSPHINOYL-PENTANE (DAPA-2-5) EN TANT QUE MÉDICAMENT TOPIQUE POUR LE TRAITEMENT DE L'INCONFORT DU TISSU ÉPITHÉLIAL STRATIFIÉ NON KÉRATINISÉ
  申请人：WEI EDWARD TAK

  公开号：WO2015059433A1

  公开（公告）日：2015-04-30

  The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to a particular di-alkyl-phosphinoyl- alkane, 1-di(sec-butyl)-phosphinoyl-pentane, referred to herein as "DAPA-2-5". Surprisingly and unexpectedly, DAPA-2-5, is able to treat (e.g., suppress) sensory discomfort from non-keratinized stratified epithelium (NKSE) selectively, that is, without the problems of stinging or irritancy, for example, as found with structurally similar compounds. As described herein, DAPA-2-5 is able to evoke a dynamic cooling sensation on non-keratinized body surfaces (including, e.g., nasopharyngeal, oropharyngeal, pharyngeal, esophageal, and anogenital surfaces) which is not accompanied by stinging or other irritative sensations. Consequently, DAPA-2-5 is useful, for example, in the treatment of disorders (e.g., diseases) including sensory discomfort from non-keratinized stratified epithelial (NKSE) tissue; upper aerodigestive tract discomfort; oropharyngeal discomfort; esophageal discomfort; throat irritation; 15 cough; heartburn; chest pain; anogenital discomfort; or inflammation of non-keratinized stratified epithelial (NKSE) tissue. The present invention also pertains to pharmaceutical compositions comprising DAPA-2-5, and the use of DAPA-2-5 and DAPA-2-5 compositions, for example, in therapy.

  本发明涉及治疗化合物领域。更具体地，本发明涉及一种特定的二烷基膦酰基烷，1-二(正丁基)-膦酰基-戊烷，此处称为“DAPA-2-5”。令人惊讶和意外的是，DAPA-2-5能够选择性地治疗（例如抑制）非角化分层上皮（NKSE）的感觉不适，即，没有刺痛或刺激性问题，例如与结构相似的化合物发现的问题。如本文所述，DAPA-2-5能够在非角化体表面（包括例如鼻咽、口咽、咽部、食管和肛门表面）上引起动态冷却感觉，而不伴随刺痛或其他刺激性感觉。因此，DAPA-2-5在治疗疾病方面具有用途，例如治疗非角化分层上皮（NKSE）组织的感觉不适；上呼吸道消化道不适；口咽不适；食管不适；喉部刺激；咳嗽；胃灼热；胸痛；肛门不适；或非角化分层上皮（NKSE）组织的炎症。本发明还涉及包含DAPA-2-5的药物组合物，以及在治疗中使用DAPA-2-5和DAPA-2-5组合物的用途。