3-[2-Oxo-2-(pyrrolidin-1-YL)ethyl]-5-phenyl-3H,4H-thieno[2,3-D]pyrimidin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: 3-[2-Oxo-2-(pyrrolidin-1-YL)ethyl]-5-phenyl-3H,4H-thieno[2,3-D]pyrimidin-4-one
• 英文别名: 3-(2-oxo-2-pyrrolidin-1-ylethyl)-5-phenylthieno[2,3-d]pyrimidin-4-one
• 化学式: C₁₈H₁₇N₃O₂S
• mdl: MFCD08146959
• 分子量: 339.4
• InChiKey: PLVPHOJPPXFWPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  81.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] THIENO[2,3-D]PYRIMIDIN-4-ONE DERIVATIVES AS NMDAR MODULATORS AND USES RELATED THERETO<br/>[FR] DÉRIVÉS DE THIÉNO[2,3-D]PYRIMIDIN-4-ONE UTILISÉS COMME MODULATEURS DE NMDAR ET LEURS UTILISATIONS ASSOCIÉES
  申请人：UNIV EMORY

  公开号：WO2016081649A1

  公开（公告）日：2016-05-26

  The disclosure relates thieno[2,3-d]pyrimidin-4-one derivatives as modulators of NMDA receptors and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed herein or pharmaceutically acceptable salts or prodrugs thereof. In certain embodiments, the compositions disclosed herein are used for managing conditions related to cognition, typically prevention or treatment of neurological conditions related to the NMDA receptor.

  本公开涉及噻吩[2,3-d]嘧啶-4-酮衍生物作为NMDA受体调节剂及其相关用途。在某些实施例中，本公开涉及包含本文所述化合物或其药学上可接受的盐或前药的制药组合物。在某些实施例中，本文所述的组合物用于管理与认知相关的疾病，通常用于预防或治疗与NMDA受体相关的神经疾病。
• Thieno[2,3-D]pyrimidin-4-one Derivatives as NMDAR Modulators and Uses Related Thereto
  申请人：Emory University

  公开号：US20170313719A1

  公开（公告）日：2017-11-02

  The disclosure relates thieno[2,3-d]pyrimidin-4-one derivatives as modulators of NMDA receptors and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed herein or pharmaceutically acceptable salts or prodrugs thereof. In certain embodiments, the compositions disclosed herein are used for managing conditions related to cognition, typically prevention or treatment of neurological conditions related to the NMDA receptor.