Inhibition of phosphatidylinositol 3-kinase with viridin, demethoxyviridin, viridiol, demethoxyviridiol, virone, wortmannolone, and analogs thereof
申请人:ELI LILLY AND COMPANY
公开号:EP0648492A2
公开(公告)日:1995-04-19
Viridin, viridiol, demethoxyviridin, demethoxyviridiol, virone, and wortmannolone, and analogs thereof, are inhibitors of phosphatidylinositol 3-kinase. The compounds are particularly useful for inhibiting phosphatidylinositol 3-kinase in vertebrates and for treating phosphatidylinositol 3-kinase-dependent conditions, especially neoplasms, restenosis and atherosclerosis, and bone disorders in vertebrates.
病毒素、病毒唑、去甲氧基病毒素、去甲氧基病毒唑、病毒酮和沃特曼龙及其类似物是磷脂酰肌醇 3- 激酶的抑制剂。这些化合物特别适用于抑制脊椎动物体内的磷脂酰肌醇 3-激酶,以及治疗依赖磷脂酰肌醇 3-激酶的疾病,尤其是脊椎动物体内的肿瘤、血管再狭窄和动脉粥样硬化以及骨骼疾病。