deacetylcytochalasin C | 22144-81-6

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 细胞松弛素类
• 英文名称: deacetylcytochalasin C
• 英文别名: (3S,3aR,6S,6aR,7E,10S,12R,13E,15R,15aR)-3,3a,6,6a,9,10,12,15-Octahydro-6,12,15-trihydroxy-4,5,10,12-tetramethyl-3-(phenylmethyl)-1H-cycloundec[d]isoindole-1,11(2H)-dione；(1R,2R,3E,5R,7S,9E,11R,12S,15R,16S)-16-benzyl-2,5,12-trihydroxy-5,7,13,14-tetramethyl-17-azatricyclo[9.7.0.01,15]octadeca-3,9,13-triene-6,18-dione
• CAS: 22144-81-6
• 化学式: C₂₈H₃₅NO₅
• 分子量: 465.59
• InChiKey: AOIKFORBJLUJGZ-NIOUNHJPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  34
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 deacetylcytochalasin C 在 吡啶 作用下， 以1.8 g的产率得到acetylcytochalasin C
  参考文献：
  名称：

  Zygosporin D and Two New Cytochalasins Produced by the Fungus Metarrhizium anisopliae

  摘要：

  Zygosporin D (3) and two new cytochalasins (4 and 5) were isolated from the culture filtrate of the fungus Metarrhizium anisopliae and characterized on the basis of their spectral data and chemical conversions. The new cytochalasins, 4 and 5, were determined to be deacetylcytochalasin C and (6R,16S,18R,2LR)-18,21-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-13(E),19(E)-diene-1,7,17-trione, respectively. Of these three cytochalasins, only zygosporin D is an effective inhibitor of shoot elongation of rice seedlings.

  DOI：

  10.1021/np990331t