acetonyl phosphate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: acetonyl phosphate
• 英文别名: Tris(2-oxopropyl) phosphate
• 化学式: C₉H₁₅O₇P
• 分子量: 266.188
• InChiKey: AHUMQLPXOOVZSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  96
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  acetonyl phosphate 在 lithium bromide 作用下， 以 丙酮 为溶剂， 以79%的产率得到Lithium;bis(2-oxopropyl) phosphate
  参考文献：
  名称：

  Koser, Gerald F.; Chen, Kuanchiang; Huang, Yali, Journal of the Chemical Society. Perkin transactions I, 1994, # 11, p. 1375 - 1376

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(三甲基硅氧基)丙烯 在 磷酸 、 4-二氟化碘甲苯 作用下， 以 叔丁醇 为溶剂， 以64%的产率得到acetonyl phosphate
  参考文献：
  名称：

  Koser, Gerald F.; Chen, Kuanchiang; Huang, Yali, Journal of the Chemical Society. Perkin transactions I, 1994, # 11, p. 1375 - 1376

  摘要：

  DOI：

文献信息

• Cardiolipin compositions their methods of preparation and use
  申请人：Ahmad U. Moghis

  公开号：US20050181037A1

  公开（公告）日：2005-08-18

  The invention provides new synthetic routes for cardiolipin with different fatty acids and/or alkyl chains with varying chain length and also with or without unsaturation. The reaction schemes can be used to generate new forms of cardiolipin, including cardiolipin variants. The cardiolipin prepared by the present methods can conveniently be incorporated into liposomes and other lipid formulations that can also include active agents such as hydrophobic or hydrophilic drugs. Such formulations can be used to treat diseases or in diagnostic and/or analytical assays. Liposomes also can include ligands, e.g., for targeting them to a cell type or specific tissue.

  本发明提供了一种用于合成不同脂肪酸和/或不同碳链长度以及有或没有不饱和度的磷脂酰肌醇的新合成路线。反应方案可用于生成新形式的磷脂酰肌醇，包括磷脂酰肌醇变异体。通过本方法制备的磷脂酰肌醇可以方便地被纳入脂质体和其他脂质制剂中，这些制剂也可以包括疏水性或亲水性药物等活性剂。这样的制剂可用于治疗疾病或在诊断和/或分析测定中使用。脂质体还可以包括配体，例如用于将其定向到特定细胞类型或组织的配体。
• Koser Gerald F., Chen Kuanchiang, Huang Yali, Summers Carol A., J. Chem. Soc. Perkin Trans. 1, (1994) N 11, S 1375-1376
  作者：Koser Gerald F., Chen Kuanchiang, Huang Yali, Summers Carol A.

  DOI：——

  日期：——
• CARDIOLIPIN COMPOSITIONS, METHODS OF PREPARATION AND USE
  申请人：Neopharm, Inc.

  公开号：EP1513853A2

  公开（公告）日：2005-03-16
• [EN] CARDIOLIPIN COMPOSITIONS THEIR METHODS OF PREPARATION AND USE<br/>[FR] COMPOSITIONS DE CARDIOLIPINE, LEURS PROCEDES DE PREPARATION ET D'UTILISATION
  申请人：NEOPHARM INC

  公开号：WO2003099830A2

  公开（公告）日：2003-12-04

  The invention provides new synthetic routes for cardiolipin with different fatty acids and/or alkyl chains with varying chain length and also with or without unsaturation. The reaction schemes can be used to generate new forms of cardiolipin, including cardiolipin variants. The cardiolipin prepared by the present methods can conveniently be incorporated into liposomes and other lipid formulations that can also include active agents such as hydrophobic or hydrophilic drugs. Such formulations can be used to treat diseases or in diagnostic and/or analytical assays. Liposomes also can include ligands, e.g., for targeting them to a cell type or specific tissue.
• Koser, Gerald F.; Chen, Kuanchiang; Huang, Yali, Journal of the Chemical Society. Perkin transactions I, 1994, # 11, p. 1375 - 1376
  作者：Koser, Gerald F.、Chen, Kuanchiang、Huang, Yali、Summers, Carol A.

  DOI：——

  日期：——