Thymidine 3'-(1,2-dimyristoyl-sn-glycero-3-phosphate)

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核糖核苷3'-磷酸盐
• 英文名称: Thymidine 3'-(1,2-dimyristoyl-sn-glycero-3-phosphate)
• 英文别名: [(2R)-3-[hydroxy-[(2R,3S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxyphosphoryl]oxy-2-tetradecanoyloxypropyl] tetradecanoate
• 化学式: C₄₁H₇₃N₂O₁₂P
• 分子量: 817.011
• InChiKey: BPRGAEKCCAXQET-LADGJGSJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.3
• 重原子数：
  56
• 可旋转键数：
  36
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  187
• 氢给体数：
  3
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  BOC-L-苯丙氨酸 、 Thymidine 3'-(1,2-dimyristoyl-sn-glycero-3-phosphate) 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  Amino Acid–Nucleotide–Lipids: Effect of Amino Acid on the Self-Assembly Properties

  摘要：

  Hybrid amphiphiles composed of a lipid covalently linked to biomolecules are attracting considerable attention, owing to their unique physicochemical and biological properties. Herein, we have synthesized novel amino acid nucleotide lipids (ANLs), presenting phenylalanine and thymidine residues and saturated or unsaturated diacyl glycerol lipid moieties to investigate the effect of the specific aminoacid moieties on both aggregation properties and interactions of ANLs with single strand polyA RNA. Physicochemical studies (DLS, cryo-TEM, and small angle X-ray scattering) indicate that phenylanaline amino acids inserted at the S' position of the nucleotide lipids stabilize multilamellar systems, whereas unilamellar vesicles are formed preferentially in the case of nucleotide lipids (NLs). Both NLs and ANLs exhibit weak interactions with complementary polyA RNA as revealed by isothermal titration calorimetry investigations The multilamellar vesicles obtained with ANLs could be used as a versatile carrier, suitable for both hydrophobic and hydrophilic therapeutic molecules.

  DOI：

  10.1021/la400515m

文献信息

• Method for Preparing Nanoparticles Based on Functional Amphiphilic Molecules or Macromolecules, and the Use Thereof
  申请人：Barthelemy Philippe

  公开号：US20110059180A1

  公开（公告）日：2011-03-10

  The invention relates to a method for preparing nanoparticles based on functional amphiphilic molecules or macromolecules, optionally in the presence of at least one colipide, enabling the encapsulation of therapeutic agents, especially anti-tumoral agents, and the use thereof for the transport and vectorisation of therapeutic agents, especially anti-tumoral agents.

  这项发明涉及一种基于功能性两性分子或大分子制备纳米颗粒的方法，可选地在至少一种胆固醇类物质的存在下，使治疗剂，特别是抗肿瘤剂的封装成为可能，并且用于运输和载体化治疗剂，特别是抗肿瘤剂。
• FUNCTIONAL AMPHIPILIC MOLECULE OR MACROMOLECULE FORMULATIONS WITH MULTIPLE COMPARTMENTS
  申请人：Barthelemy Philippe

  公开号：US20120070505A1

  公开（公告）日：2012-03-22

  The invention relates to novel functional amphiphilic molecule or macromolecule formulations with multiple compartments for transporting or targeting at least one therapeutic agent, in particular an antitumor agent, as well as to a method for preparing such formulations and to the use thereof.

  本发明涉及一种新型的具有多个隔室的功能性两性分子或大分子配方，用于运输或靶向至少一种治疗剂，特别是抗肿瘤剂，以及制备这种配方的方法和使用方法。
• METHOD FOR PREPARING NANOPARTICLES BASED ON FUNCTIONAL AMPHIPHILIC MOLECULES OR MACROMOLECULES, AND THE USE THEREOF
  申请人：UNIVERSITE VICTOR SEGALEN BORDEAUX 2

  公开号：US20140308343A1

  公开（公告）日：2014-10-16

  The invention relates to a method for preparing nanoparticles based on functional amphiphilic molecules or macromolecules, optionally in the presence of at least one colipide, enabling the encapsulation of therapeutic agents, especially anti-tumoral agents, and the use thereof for the transport and vectorization of therapeutic agents, especially anti-tumoral agents.

  本发明涉及一种基于功能性两亲分子或大分子的纳米粒子制备方法，可选地在至少一种胆固醇类物质的存在下，使治疗剂，特别是抗肿瘤剂封装，并用于治疗剂，特别是抗肿瘤剂的输送和载荷。
• PROCÉDÉ DE PRÉPARATION DE NANOPARTICULES À BASE DE MOLÉCULES OU MACROMOLÉCULES AMPHIPHILES FONCTIONNELLES ET LEUR UTILISATION
  申请人：Université Victor Segalen Bordeaux 2

  公开号：EP2231132A2

  公开（公告）日：2010-09-29
• Formulations à compartiments multiples à base de molécules ou macromolécules amphiphiles fonctionnelles
  申请人：Université de Bordeaux

  公开号：EP2435031B1

  公开（公告）日：2015-09-16