N-(4-isopropylphenyl)-3-(4-oxo-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidin-2-yl)propanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: N-(4-isopropylphenyl)-3-(4-oxo-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidin-2-yl)propanamide
• 英文别名: 3-(4-oxo-5,6,7,8-tetrahydro-3H-[1]benzothiolo[2,3-d]pyrimidin-2-yl)-N-(4-propan-2-ylphenyl)propanamide
• 化学式: C₂₂H₂₅N₃O₂S
• mdl: MFCD10589316
• 分子量: 395.5
• InChiKey: BATZRLTVRFIUKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  98.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Methods for treatment of retinal disease by photoreceptor gene expression modulation
  申请人：University of Washington

  公开号：US10363256B2

  公开（公告）日：2019-07-30

  Methods for decreasing rod gene expression in a retina, methods for decreasing the protein products expressed by rod genes in a retina, methods for treating a disease or condition treatable by decreasing rod gene expression or their protein products in a retina, and methods for treating a retinal disease in a subject.

  降低视网膜中杆细胞基因表达的方法，降低视网膜中杆细胞基因表达的蛋白质产物的方法，通过降低视网膜中杆细胞基因表达或其蛋白质产物来治疗可治疗的疾病或病情的方法，以及治疗受试者视网膜疾病的方法。
• METHODS FOR TREATMENT OF RETINAL DISEASE BY PHOTORECEPTOR GENE EXPRESSION MODULATION
  申请人：University of Washington

  公开号：US20180125847A1

  公开（公告）日：2018-05-10

  Methods for decreasing rod gene expression in a retina, methods for decreasing the protein products expressed by rod genes in a retina, methods for treating a disease or condition treatable by decreasing rod gene expression or their protein products in a retina, and methods for treating a retinal disease in a subject.