phosphoric acid mono(3-dodecylmercapto-2-decyloxy)-1-propyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: phosphoric acid mono(3-dodecylmercapto-2-decyloxy)-1-propyl ester
• 英文别名: phosphoric acid-(3-dodecylmercapto-2-decyloxy)-1-propyl ester；phosphoric acid (3-dodecylmercapto-2-decyloxy)-propyl ester；phosphoric acid (3-dodecylmercapto-2-decyloxy)propyl ester；3-(3-dodecylsulfanyldecan-2-yloxy)propyl dihydrogen phosphate
• 化学式: C₂₅H₅₃O₅PS
• 分子量: 496.733
• InChiKey: QVMPJWUVHUUAAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  32
• 可旋转键数：
  25
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  phosphoric acid mono(3-dodecylmercapto-2-decyloxy)-1-propyl ester 、 脱氧助间型霉素 在 吡啶 、 甲烷磺酸 作用下， 以27%的产率得到[3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,6,7,8 tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol]-5'-phosphoric Acid-(3-dodecylmercapto-2-decyloxy)-propyl Ester
  参考文献：
  名称：

  LIPID CLEAVAGE ENZYME

  摘要：

  一种尚未在现代技术中描述的膜酶可以从血液白细胞或单核/巨噬细胞的细胞膜分离物中提取。还公开了使用该酶底物制备含有这些底物作为药物活性成分的药物的用途。这些药物可用于将药理活性物质定向到目标细胞并用该物质富集目标细胞。还公开了含有该酶的体外研究系统，用于检测该酶的其他底物。

  公开号：

  US20020106363A1
• 作为产物：
  描述：

  四磷十氧化物 、 六甲基二硅氧烷 、 (R)-3-dodecylmercapto-2-decyloxy-1-propanol 以 吡啶 为溶剂， 反应 1.0h， 生成 phosphoric acid mono(3-dodecylmercapto-2-decyloxy)-1-propyl ester
  参考文献：
  名称：

  Liponucleotides of seco-nucleosides, their production as well as their

  摘要：

  本发明涉及一种新的磷脂衍生物，其中包括将一种代表取代C3骨架的脂肪基与acyclovir或ganciclovir通过磷酸酯或硫代磷酸酯连接。这些化合物特别适用于治疗病毒感染。

  公开号：

  US06080734A1

文献信息

• Lipid esters of nucleoside monophosphates and their use as
  申请人：Roche Diagnostics GmbH

  公开号：US06025343A1

  公开（公告）日：2000-02-15

  The present invention is directed to new nucleoside monophosphate derivatives of lipid ester residues of general formula (I) ##STR1## wherein R.sup.1 represents an optionally substituted alkyl chain having 1-20 carbon atoms; R.sup.2 represents hydrogen, an optionally substituted alkyl chain having 1-20 carbon atoms; R.sup.3, R.sup.4 and R.sup.5 represent hydrogen, hydroxy, azido, amino, cyano, or halogen; X represents a valence dash, oxygen, sulfur, a sulfinyl or sulfonyl group; Y represents a valence dash, an oxygen or sulfur atom; B represents a purine and/or pyrimidine base; with the proviso that at least one of the residues R.sup.3 or R.sup.5 is hydrogen; to their tautomers and their physiologically acceptable salts of inorganic and organic acids and/or bases, as well as to processes for their preparation, and to drugs containing said compounds.

  本发明涉及一种新的核苷酸单磷酸脂酯残基的衍生物，其通式为(I)其中R.sup.1代表具有1-20个碳原子的可选择取代的烷基链；R.sup.2代表氢，一个具有1-20个碳原子的可选择取代的烷基链；R.sup.3、R.sup.4和R.sup.5代表氢，羟基，叠氮基，氨基，氰基或卤素；X代表一个价键，氧，硫，亚砜基或磺酰基；Y代表一个价键，一个氧或硫原子；B代表嘌呤和/或嘧啶碱基；但规定R.sup.3或R.sup.5中至少有一个残基为氢；它们的互变异构体及其生理上可接受的无机和有机酸和/或碱盐，以及其制备方法和含有所述化合物的药物。
• Phospholipid esters of clofarabine derivatives
  申请人：Heidelberg Pharma Holding GmbH

  公开号：EP1460082A1

  公开（公告）日：2004-09-22

  The subject of the present invention are specific lipidesters of halogenated-adenine nucleotides and the use of such lipidesters in the treatment of tumors.

  本发明涉及卤腺嘌呤核苷酸的特定脂质酯及其在肿瘤治疗中的应用。
• Nucleoside monophosphate derivative, a processor for their production and their use as immunosuppressive drugs
  申请人：Heidelberg Pharma Holding GmbH

  公开号：EP1229040A2

  公开（公告）日：2002-08-07

  The present invention is directed to new nucleoside monophosphate derivatives of lipid ester residues of general formula (I)    wherein R1may be a straight-chain or branched, saturated or unsaturated alkyl chain having 1-20 carbon atoms, R2may be hydrogen, a straight-chain or branched, saturated or unsaturated alkyl chain having 1-20 carbon atoms, Xrepresents sulfur, a sulfinyl or sulfonyl group;and Nucl. represents    2',3'-Didesoxy-2',3'-difluorothymidine    2'-Desoxy-2'-aminoadenosine    2'-Desoxy-2'-azidoadenosine    2'-Desoxy-2'-azidocytidine    2'-Desoxy-5-fluorouridine    2-Fluoro-2'-desoxyadenosine their tautomers and their physiologically acceptable salts of inorganic and organic acids and/or bases, as well as to processes for their preparation, and to drugs containing said compounds.

  本发明涉及通式(I)的脂酯残基的新的单磷酸核苷衍生物 其中 R1可以是具有 1-20 个碳原子的直链或支链、饱和或不饱和烷基链、 R2 可以是氢、具有 1-20 个碳原子的直链或支链、饱和或不饱和烷基链、 X 代表硫、亚砜基或磺酰基；以及 Nucl. 2',3'-二脱氧-2',3'-二氟胸苷 2'-脱氧-2'-氨基腺苷 2'-脱氧-2'-叠氮腺苷 2'-脱氧-2'-叠氮胞苷 2'-脱氧-5-氟尿苷 2-氟-2'-脱氧腺苷 它们的同系物和它们在生理上可接受的无机酸和有机酸和/或碱的盐，以及它们的制备工艺和含有上述化合物的药物。
• Lapid cleavage enzyme
  申请人：Heidelberg Pharma Holding GmbH

  公开号：US20030082167A1

  公开（公告）日：2003-05-01

  A membranous enzyme not yet described in the state-of-the-art can be extracted from cellular membrane fractions of blood leukocytes or monocytes/macrophages. Also disclosed is the use of substrates of this enzyme to prepare medicaments that contain these substrates as pharmaceutical active substance. These medicaments are useful to direct pharmacologically active substances to target cells and to enrich target cells with said substances. Also disclosed are in-vitro research systems containing this enzyme used to detect other substrates of this enzyme.

  可以从血液白细胞或单核细胞/巨噬细胞的细胞膜分馏物中提取一种尚未在最新技术中描述的膜酶。 还公开了利用这种酶的底物制备含有这些底物作为药用活性物质的药物。 这些药剂可将药理活性物质导向靶细胞，并用上述物质富集靶细胞。 还公开了含有这种酶的体外研究系统，用于检测这种酶的其它底物。
• Phospholepid derivatives of nucleosides as antitumaorl medicaments
  申请人：Herrmann Dieter

  公开号：US20050090659A1

  公开（公告）日：2005-04-28

  The present invention relates to drugs containing phospholipid derivatives preferably of non-natural nucleosides corresponding to general formula I: in which R 1 represents an alkyl chain with 10-14 carbon atoms, R 2 represents an alkyl chain with 8-12 carbon atoms, n represents an integer equal to 0 to 2, R 3 represents a hydroxy group, R 4 and R 5 represent hydrogen, and B represents 5-fluorouracil, for use as antitumoral or antiproliferative active ingredients for the prophylaxis and/or curative, palliative or supportive treatment of tumor diseases or neoplasias, such as for example carcinomas, sarcomas, lymphomas or leukemias, both as therapeutic or prophylactic agents for monotherapy and in free or fixed combination with other modalities of prophylaxis or therapy.

  本发明涉及含有磷脂衍生物的药物，最好是通式 I 所对应的非天然核苷的磷脂衍生物： 其中 R 1 代表含有 10-14 个碳原子的烷基链、 R 2 代表具有 8-12 个碳原子的烷基链，n 代表等于 0-2 的整数、 R 3 代表羟基、 R 4 和 R 5 代表氢，B 代表 5-氟尿嘧啶，用作抗肿瘤或抗增生活性成分，用于预防和/或治疗、缓解或支持性治疗肿瘤疾病或肿瘤，例如癌、肉瘤、淋巴瘤或白血病，既可作为治疗剂或预防剂用于单一疗法，也可与其他预防或治疗方式自由或固定组合使用。