phosphacycloheptane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 磷环化合物
• 英文名称: phosphacycloheptane
• 英文别名: phosphepane
• 化学式: C₆H₁₃P
• 分子量: 116.143
• InChiKey: JAOLNXGJDXODBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  [Cp*Fe{η⁴-P₅(C₆H₁₂)}] 在 lithium aluminium tetrahydride 作用下， 以73 %的产率得到phosphacycloheptane
  参考文献：
  名称：

  （母体）phosphetanes、phospholanes、phosphines 和 phosphepanes 的新合成路线

  摘要：

  报道了一种用于（母体）含磷环烷烃（如磷杂环戊烷、磷杂环戊烷、膦烷和磷杂环己烷）的新合成路线。通过使用 [K(dme) 2 ] 2 [Cp*Fe(η 4 -P 5 )] ( I ) 与 α,ω-二溴烷烃 C n H 2 n Br 2 [ n = 3–6]，独特的磷化烷, phospholane, phosphinane 和 phospepane 前体复合物 [Cp*Fe{η 4 -P 5 (CH 2 ) n }] [ n = 3–6] ( 2–5) 合成。它们充当 P 原子载体，相应的磷杂环丁烷、磷杂环戊烷、膦烷和磷杂环己烷 ( 6–9 ) 可由亲核试剂释放，即苄基钾 (KBn) 或 LiAlH 4。后者能够以简单直接的方式选择性合成母体环状仲膦 ( 10 )，包括第一母体磷杂环丁烷 ( 10b )。

  DOI：

  10.1039/d3sc00580a

文献信息

• CARBOXYLATE METAL COMPLEX AND CATALYST FOR OLEFIN POLYMERIZATION
  申请人：Ito Shingo

  公开号：US20130158223A1

  公开（公告）日：2013-06-20

  The present invention provides a metal complex of group 10 elements of the periodic table having a carboxylate structure represented by formula (C2); a catalyst for polymerization of olefin mainly comprising the metal complex; and a method for producing polymers by homopolymerizing olefin represented by formula (1), polymerizing two or more kinds of the above olefin, or copolymerizing olefin represented by formula (1) with polar group-containing olefin represented by formula (2) (the meaning of the symbols are as set forth in the description) using the catalyst. A metal complex of group 10 elements of the periodic table, in which all of the coordinating atoms to the metal are a hetero atom is stable and useful as a catalyst component for olefin polymerization, and can be used for a long time in homopolymerization of olefin or copolymerization of two or more kinds of olefin.

  本发明提供了一种具有由式（C2）表示的羧酸盐结构的周期表第10族元素的金属配合物；主要包括所述金属配合物的烯烃聚合催化剂；以及通过使用所述催化剂，通过将由式（1）表示的烯烃进行均聚合，聚合两种或更多种上述烯烃，或将由式（1）表示的烯烃与由式（2）表示的含极性基团的烯烃进行共聚合来生产聚合物的方法。周期表第10族元素的金属配合物，其中与金属配位的所有原子均为杂原子，稳定且可用作烯烃聚合的催化剂组分，并可在烯烃的均聚合或两种或更多种烯烃的共聚合中长时间使用。
• Tetrahydrocarbazol derivatives as ligands for G-protein-coupled receptors (GPCR)
  申请人：ZENTARIS AG

  公开号：US20030232873A1

  公开（公告）日：2003-12-18

  This invention provides new tetrahydrocarbazole derivatives that act as ligands for G-protein-coupled receptors (GPCR), especially as antagonists of the gonadotropin-releasing hormone (GnRH). A pharmaceutical composition that contains these new tetrahydrocarbazole derivatives as well as a process for the production of the new tetrahydrocarbazole derivatives are also provided. Moreover, this invention relates to the administration of tetrahydrocarbazole derivatives for treating pathologic conditions that are mediated by GPCR, especially for inhibiting GnRH, in mammals, especially humans, who require such an administration, as well as the use of tetrahydrocarbazole derivatives for the production of a pharmaceutical agent for treating GPCR-mediated pathologic conditions, especially for inhibiting GnRH.

  这项发明提供了作为G蛋白偶联受体（GPCR）配体的新四氢咔唑衍生物，特别是作为促性腺激素释放激素（GnRH）的拮抗剂。还提供了一种含有这些新四氢咔唑衍生物的药物组合物，以及一种生产这些新四氢咔唑衍生物的方法。此外，这项发明涉及给哺乳动物，特别是人类，需要这种给药的通过四氢咔唑衍生物治疗GPCR介导的病理状况，特别是抑制GnRH的治疗，以及利用四氢咔唑衍生物生产用于治疗GPCR介导的病理状况，特别是抑制GnRH的药物的用途。
• SILYLPHOSPHINE - ALKENE REACTION ROUTES TO ACYCLIC AND CYCLIC ORGANOPHOSPHINES
  作者：David M. Schubert、Michael L. J. Hackney、Paul F. Brandt、Arlan D. Norman

  DOI：10.1080/10426509708044204

  日期：1997.4.1

  Abstract Radical reactions of Me3SiPH2, (Me3Si)2PH, Me2Si(PH2)2 and PH3 with selected alkenes have been examined as routes to new organo(silyl)phosphines. The Me3SiPH2/1,5-hexadiene reaction initiated by AIBN yields the phosphepane Me3SiP(CH2)6 (11a) and acyclic Me3SiP[(CH2)4CH=CH2]2 (12); the Me3SiPH2/1,3-butadiene reaction yields only acyclic butenyl phosphines Me3SiP(H)C4H7 (14a - C) and Me3SiP(C4H7)2

  摘要 Me3SiPH2、(Me3Si)2PH、Me2Si(PH2)2 和 PH3 与选定烯烃的自由基反应已被研究作为获得新有机（甲硅烷基）膦的途径。由 AIBN 引发的 Me3SiPH2/1,5-己二烯反应生成磷烷 Me3SiP(CH2)6 (11a) 和无环 Me3SiP[( )4CH= ]2 (12)；Me3SiPH2/1,3-丁二烯反应仅产生无环丁烯基膦 Me3SiP(H)C4H7 (14a - C) 和 Me3SiP( )2 (15a - D)。Me3SiPH2 与 P(CH= )3 和 MeSi(CH= )3 反应生成乙烯基取代的顺式和反式膦烷 ( =CH)P(C2H4)2PSiMe3 (18a/18b) 和 Me( = CH)Si( )、PSiMe3 (20a/20b)。(Me2Si)2PH/Me2Si(CH= )2 反应仅产生无环的 (
• Curcumol derivatives, the compositions containing the said derivatives, and the use of the same in the manufacture of medicaments
  申请人：Wang Shulong

  公开号：US20070191360A1

  公开（公告）日：2007-08-16

  The present invention provides curcumol derivatives of the following formula (I) or pharmaceutical acceptable salts thereof: wherein, Y is selected from the group consisting of ═CHR 2 , —CH 2 R 2 , ═O, —OH or —OR 1 ;R 1 is selected from H, R, RCO or HO 3 S; and R is selected from the group consisting of H; saturated or unsaturated linear C 1-10 hydrocarbon group and the like; R 2 is selected from the group consisting of F; Cl; Br; I; H; —OH; —OR; —HSO 3 and the like; with the proviso that both R 1 and R 2 are not H. The present invention also provides anti-tumor or antiviral pharmaceutical compositions comprising said derivatives or pharmaceutical acceptable salts thereof. The present invention further provides the use of said derivatives or pharmeceutical acceptable salts thereof in the preparation of a medicament for prophylaxis and/or treatment tumor or an antiviral medicament.

  本发明提供以下式（I）的姜黄醇衍生物或其药学上可接受的盐：其中，Y选自 ═CHR2，—CH2R2，═O，—OH或—OR1的群组；R1选自H，R，RCO或HO3S；R选自H；饱和或不饱和的线性C1-10烃基等群组；R2选自F，Cl，Br，I，H，—OH，—OR，—HSO3等群组；但要求R1和R2均不为H。本发明还提供包含上述衍生物或其药学上可接受的盐的抗肿瘤或抗病毒药物组合物。本发明还提供使用上述衍生物或其药学上可接受的盐制备预防和/或治疗肿瘤或抗病毒药物的药物。
• Chiral ligands
  申请人：Solvias AG

  公开号：EP2186817A1

  公开（公告）日：2010-05-19

  Process for preparing ligands of the formula (1), in which R1 is C1-C8-alkyl, unsubstituted cyclopentyl, cyclohexyl, norbornyl or adamantyl, or cyclopentyl or cyclohexyl, substituted by 1 to 3 C1-C4-alkyl or C1-C4-alkoxy, or benzyl, phenyl, naphthyl and anthryl which are unsubstituted or substituted by 1 to 3 C1-C4-alkyl, C1-C4-alkoxy, C1-C4-fluoroalkyl or C1-C4-fluoroalkoxy, F and Cl, each of R2 and R3 is independently a C-bonded hydrocarbon radical or a heterohydrocarbon radical, and R4 is C1-C4-alkyl, cyclopentyl, cyclohexyl, phenyl, methylphenyl, methylbenzyl or benzyl, which comprises (a) stereoselective metallation in ortho position to the amine side-chain of a compound of formula (A) in which R4 is as defined above, reaction with a dihalide of formula R1-PX2 in which R1 is as defined above and X is Cl or Br, stereoselective hydrolysis to give a compound containing an SPO group, and reaction with a secondary phosphine of formula H-PR2R3 in which R2 and R3 are as defined above, to give the compounds of formula (1). New ligands obtained by that process and metal complexes thereof.

  制备式（1）配体的工艺、 其中 R1 是 C1-C8- 烷基、未取代的环戊基、环己基、降冰片基或金刚烷基，或被 1 至 3 个 C1-C4- 烷基或 C1-C4- 烷氧基取代的环戊基或环己基，或未取代或被 1 至 3 个 C1-C4- 烷基、C1-C4-烷氧基、C1-C4-氟烷基或 C1-C4- 氟烷氧基、F 和 Cl 取代的苄基、苯基、萘基和蒽基、 R2 和 R3 各自独立地是一个 C 键烃基或一个杂烃基，以及 R4 是 C1-C4 烷基、环戊基、环己基、苯基、甲基苯基、甲基苄基或苄基、 其中包括 (a) 在式 (A) 化合物胺侧链的正交位置进行立体选择性金属化 其中 R4 如上定义、 与式 R1-PX2 的二卤化物（其中 R1 如上定义，X 为 Cl 或 Br）反应，立体选择性水解，得到含有 SPO 基团的化合物，再与式 H-PR2R3 的仲膦反应（其中 R2 和 R3 如上定义），得到式（1）化合物。 通过该工艺得到的新配体及其金属配合物。