二硫代碳酸S-(8-甲基-8-氮杂双环[3.2.1]辛烷-3-基)酯

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 中文名称: 二硫代碳酸S-(8-甲基-8-氮杂双环[3.2.1]辛烷-3-基)酯
• 中文别名: 托品-3-基黄原酸酯
• 英文名称: (3-hydroxy-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl)sulfanylmethanethioate
• 化学式: C9H15NO2S2
• 分子量: 233.4
• InChiKey: TVRWQAGMFWLARE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] NOVEL PROCESS, SALTS, COMPOSITIONS AND USE<br/>[FR] PROCEDE, SELS, COMPOSITIONS ET UTILISATION
  申请人：GLAXO GROUP LTD

  公开号：WO2005023257A1

  公开（公告）日：2005-03-17

  The present invention provides a novel process for preparing pleuromutilin derivatives, novel salts of mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.l]oct-3-ylsulfanyl)-acetate or solvates thereof, novel pharmaceutical compositions or formulations for topical administration comprising mutilin 14-(exo-8- methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)-acetate or a pharmaceutically acceptable salt or solvate thereof and their use in medical therapy, particularly antibacterial therapy.

  本发明提供了一种新型制备螨素衍生物的方法，以及新型的螨素14-(exo-8-甲基-8-氮杂双环[3.2.1]辛-3-基硫基)-乙酸酯或其溶剂化合物的盐，用于局部给药的新型药物组合物或制剂，包括螨素14-(exo-8-甲基-8-氮杂双环[3.2.1]辛-3-基硫基)-乙酸酯或其药用可接受的盐或溶剂化合物，并且在医疗治疗中的应用，特别是抗菌治疗。
• Novel process salts compositions and use
  申请人：Breen Francis Gary

  公开号：US20060276503A1

  公开（公告）日：2006-12-07

  The present invention provides a novel process for preparing pleuromutilin derivatives, novel salts of mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)-acetate or solvates thereof, novel pharmaceutical compositions or formulations for topical administration comprising mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)-acetate or a pharmaceutically acceptable salt or solvate thereof and their use in medical therapy, particularly antibacterial therapy.

  本发明提供了一种制备杀菌素衍生物的新工艺，杀菌素14-（外消旋-8-甲基-8-氮杂双环[3.2.1]辛烷-3-基硫醇）-乙酸盐的新盐或其溶剂化物，以及包含杀菌素14-（外消旋-8-甲基-8-氮杂双环[3.2.1]辛烷-3-基硫醇）-乙酸盐或其药学上可接受的盐或溶剂化物的新型局部给药的药物组合物或制剂，以及它们在医疗治疗中的使用，特别是在抗菌治疗中的应用。
• NOVEL PROCESS, SALTS, COMPOSITION AND USE
  申请人：Breen Gary Francis

  公开号：US20110144151A1

  公开（公告）日：2011-06-16

  The present invention provides a novel process for preparing pleuromutilin derivatives, novel salts of mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)-acetate or solvates thereof, novel pharmaceutical compositions or formulations for topical administration comprising mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)-acetate or a pharmaceutically acceptable salt or solvate thereof and their use in medical therapy, particularly antibacterial therapy.

  本发明提供了一种制备噻唑菌素衍生物的新工艺，以及新的噻唑霉素14-(外消旋-8-甲基-8-氮杂双环[3.2.1]辛-3-基硫酰基)乙酸盐或其溶剂化物，新的药物组合物或制剂，用于局部给药，包括噻唑霉素14-(外消旋-8-甲基-8-氮杂双环[3.2.1]辛-3-基硫酰基)乙酸盐或其药学上可接受的盐或溶剂化物，并用于医疗治疗，特别是抗菌治疗。
• Salts and crystalline form of mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl-sufanyl)-acetate
  申请人：Glaxo Group Limited

  公开号：EP2181995A2

  公开（公告）日：2010-05-05

  The present invention provides a novel process for preparing pleuromutilin derivatives, novel salts of mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)-acetate or solvates thereof, novel pharmaceutical compositions or formulations for topical administration comprising mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)-acetate or a pharmaceutically acceptable salt or solvate thereof and their use in medical therapy, particularly antibacterial therapy.

  本发明提供了一种制备胸腺嘧啶衍生物、14-(外向-8-甲基-8-氮杂双环[3.2.1]辛-3-基硫基)-乙酸酯或其溶液的新型盐、包含 14-(外向-8-甲基-8-氮杂双环[3.2.1]辛-3-基硫基)-乙酸酯或其药学上可接受的盐或溶液的用于局部用药的新型药物组合物或制剂的新型工艺。2.1]oct-3-ylsulfanyl)-acetate 或其药学上可接受的盐或溶液，以及它们在医学治疗，尤其是抗菌治疗中的用途。
• NOVEL PROCESS FOR THE PREPARATION OF PLEUROMUTILIN DERIVATIVES
  申请人：GLAXO GROUP LIMITED

  公开号：EP1663220B1

  公开（公告）日：2009-12-02