ethyl [(2-chloroethyl)methylamido]chlorophosphate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: ethyl [(2-chloroethyl)methylamido]chlorophosphate
• 英文别名: 2-chloro-N-[chloro(ethoxy)phosphoryl]-N-methylethanamine
• 化学式: C₅H₁₂Cl₂NO₂P
• 分子量: 220.036
• InChiKey: MGLHSZJWSCKBOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  丙酮缩甘油 、 ethyl [(2-chloroethyl)methylamido]chlorophosphate 在 三乙胺 作用下， 以 苯 为溶剂， 反应 12.0h， 以18%的产率得到1,2-O-isopropylideneglycero-3-[ethyl [(2-chloroethyl)methylamido]phosphate]
  参考文献：
  名称：

  摘要：

  A promising approach to the synthesis of phosphamide lipid constructions of cationic type on the basis of cyclophosphites and -amidophosphites is considered. The latter easily undergo oxidative decyclization under the action of chlorine or bromine. The resulting halophosphates and amidohalophosphates take part in various reactions finally leading to models of cationic phosphatidyl cholines which are among priority objects of modern phospholipid chemistry.

  DOI：

  10.1023/a:1012319132072
• 作为产物：
  描述：

  2-ethoxy-3-methyl-1,3,2-oxazaphospholidine 在 氯 作用下， 以 氯仿 为溶剂， 反应 0.17h， 以88%的产率得到ethyl [(2-chloroethyl)methylamido]chlorophosphate
  参考文献：
  名称：

  摘要：

  A promising approach to the synthesis of phosphamide lipid constructions of cationic type on the basis of cyclophosphites and -amidophosphites is considered. The latter easily undergo oxidative decyclization under the action of chlorine or bromine. The resulting halophosphates and amidohalophosphates take part in various reactions finally leading to models of cationic phosphatidyl cholines which are among priority objects of modern phospholipid chemistry.

  DOI：

  10.1023/a:1012319132072

文献信息

• ——
  作者：D. A. Predvoditilev、S. V. Suvorkin、E. E. Nifant'ev

  DOI：10.1023/a:1012319132072

  日期：——

  A promising approach to the synthesis of phosphamide lipid constructions of cationic type on the basis of cyclophosphites and -amidophosphites is considered. The latter easily undergo oxidative decyclization under the action of chlorine or bromine. The resulting halophosphates and amidohalophosphates take part in various reactions finally leading to models of cationic phosphatidyl cholines which are among priority objects of modern phospholipid chemistry.