benzoic acid 2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenyl ester

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: benzoic acid 2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenyl ester
• 英文别名: [2-[3-[Di(propan-2-yl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl] benzoate
• 化学式: C₂₉H₃₅NO₃
• 分子量: 445.602
• InChiKey: KGNKBMFLHKBDSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Novel derivatives of 3,3-diphenylpropylamines
  申请人：Schwarz Pharma AG

  公开号：US20040186061A1

  公开（公告）日：2004-09-23

  The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compouds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.

  本发明涉及3,3-二苯基丙胺衍生物的新型衍生物，其制备方法，含有新型化合物的药物组合物以及用于制备药物的化合物的用途。更具体地说，本发明涉及优于现有药物如奥克西布丁和托尔特罗定的抗胆碱药物的新型前药，其药代动力学性质更优，其制备方法，含有它们的药物组合物，一种使用所述化合物和组合物治疗尿失禁，胃肠道过度活跃（肠易激综合征）和其他平滑肌收缩症状的方法。
• NOVEL DERIVATIVES OF 3,3-DIPHENYLPROPYLAMINES
  申请人：Meese Claus

  公开号：US20090042981A1

  公开（公告）日：2009-02-12

  The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compounds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.

  本发明涉及3,3-二苯基丙胺的新衍生物，其制备方法，含有新化合物的药物组成物以及用于制备药物的化合物的使用。更具体地说，本发明涉及抗胆碱能药物的新型前药，其药代动力学性质优于现有药物，如奥沙利铂和托尔吡啶，其制备方法，含有它们的药物组成物，使用上述化合物和组成物治疗尿失禁，胃肠道高活性（肠易激综合征）和其他平滑肌收缩症状的方法。
• CHIRAL INTERMEDIATE, PROCESS FOR PRODUCING THE SAME AND ITS USE IN THE MANUFACTURE OF TOLTERODINE, FESOTERODINE, OR THE ACTIVE METABOLITE THEREOF
  申请人：MEESE Claus

  公开号：US20110245338A1

  公开（公告）日：2011-10-06

  The compound of formula (I): is provided. It may be produced by subjecting a compound of formula (IV) to a reduction reaction wherein R represents hydrogen, straight or branched C 1 -C 6 alkyl. This compound is a valuable intermediate which may be used in the synthesis of fesoterodine, tolterodine, its active metabolite, and related compounds.

  提供公式（I）的化合物。它可以通过将公式（IV）的化合物经过还原反应制备而成，其中R代表氢，直链或支链C1-C6烷基。该化合物是一种有价值的中间体，可用于合成费索特罗定、托尔吡啶及其活性代谢产物和相关化合物。
• Derivatives of 3,3-diphenylpropylamines
  申请人：SCHWARZ PHARMA AG

  公开号：EP1254890A1

  公开（公告）日：2002-11-06

  The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compounds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.

  本发明涉及 3,3-二苯基丙胺的新型衍生物、其制备方法、含有该新型化合物的药物组合物以及使用该化合物制备药物。更具体地说，本发明涉及与现有药物（如奥昔布宁和托特罗定）相比具有更优越的药代动力学特性的新型抗心绞痛药物原药、其制备方法、含有这些原药的药物组合物、使用所述化合物和组合物治疗尿失禁、胃肠动力亢进（肠易激综合征）和其他平滑肌收缩疾病的方法。
• NEW CHIRAL INTERMEDIATE, PROCESS FOR PRODUCING THE SAME AND ITS USE IN THE MANUFACTURE OF TOLTERODINE, FESOTERODINE, OR THE ACTIVE METABOLITE THEREOF
  申请人：SCHWARZ PHARMA AG

  公开号：EP2027103A1

  公开（公告）日：2009-02-25