Phenyl 2-hydroxy-4-[(3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl)amino]benzoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: Phenyl 2-hydroxy-4-[(3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl)amino]benzoate
• 化学式: C₁₇H₁₄F₃NO₅
• 分子量: 369.29
• InChiKey: AWASXVFGQAWMKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• [EN] 2-FLUORO-4-[(3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL)AMINO]BENZOATE DERIVATIVES; COMPOSITIONS CONTAINING SAME; COSMETIC USES<br/>[FR] DÉRIVÉS DE 2-FLUORO-4-[(3,3,3-TRIFLUORO-2-HYDROXY-2-MÉTHYLPROPANOYL)AMINO]BENZOATE; COMPOSITIONS LES CONTENANT; UTILISATIONS COSMÉTIQUES
  申请人：OREAL

  公开号：WO2009077387A1

  公开（公告）日：2009-06-25

  The invention relates to novel 2-fluoro-4- [ (3,3,3- trifluoro-2-hydroxy-2-methylpropanoyl) amino] benzoate derivatives of formula (I), and also a tautomeric form thereof and/or an enantiomer thereof in isolated form or as a mixture and/or a cis/trans isomer thereof in isolated form or as a mixture and/or a salt and/or a solvate thereof : Formula (I). The present invention also relates to compositions comprising these compounds. The present invention also relates to the cosmetic use of these compounds with the aim of reinforcing and/or preserving the natural antioxidant protection of the skin. The invention also relates to the cosmetic use of these same compounds with the aim of inducing and/or stimulating the growth of keratin fibres. The present invention also relates to the cosmetic use of these same compounds as an agent for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or limiting their depigmentation and/or their whitening.

  该发明涉及新型2-氟-4-[(3,3,3-三氟-2-羟基-2-甲基丙酰)氨基]苯甲酸酯衍生物的化学式(I)，以及其异构体形式和/或对映异构体在分离形式或混合形式中和/或其顺反异构体在分离形式或混合形式中和/或其盐和/或溶剂化合物：化学式(I)。本发明还涉及包含这些化合物的组合物。本发明还涉及这些化合物在化妆品中的使用，旨在增强和/或保护皮肤的天然抗氧化保护。该发明还涉及这些相同化合物在化妆品中的使用，旨在诱导和/或刺激角蛋白纤维的生长。本发明还涉及这些相同化合物在化妆品中作为促进和/或诱导和/或刺激角蛋白材料色素沉积和/或限制其脱色和/或变白的剂的使用。