(4-carbamimidoylphenyl) 4-[(E)-3-[benzyl-(2-ethoxy-2-oxoethyl)amino]-2-methyl-3-oxoprop-1-enyl]benzoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: (4-carbamimidoylphenyl) 4-[(E)-3-[benzyl-(2-ethoxy-2-oxoethyl)amino]-2-methyl-3-oxoprop-1-enyl]benzoate
• 化学式: C₂₉H₂₉N₃O₅
• 分子量: 499.6
• InChiKey: PBZZRDPUNAOUCX-LVZFUZTISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  37
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• THERAPEUTIC AGENT FOR DIABETES COMPRISING PROTEASE-INHIBITING COMPOUND
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1815865A1

  公开（公告）日：2007-08-08

  The problem of the present invention is to provide a preventive and/or therapeutic agent for diabetes and/or complications of diabetes based on the novel mode of action. The protease-inhibiting compound according to the present invention is a compound represented by the general formula (I) [wherein all the symbols have the same meanings as described in the specification], its salt or solvate, or a prodrug thereof, is useful as a preventive and/or therapeutic agent for diabetes and/or complications of diabetes.

  本发明的问题是提供一种基于新作用模式的糖尿病和/或糖尿病并发症的预防和/或治疗剂。 根据本发明的蛋白酶抑制化合物是由通式（I）代表的化合物 [其中所有符号的含义与说明书所述相同]的化合物、其盐或溶液或其原药，可用作糖尿病和/或糖尿病并发症的预防和/或治疗剂。
• Therapeutic Agent for Diabetes Comprising Protease-Inhibiting Compound
  申请人：Sakai Yoshiki

  公开号：US20080009537A1

  公开（公告）日：2008-01-10

  The problem of the present invention is to provide a preventive and/or therapeutic agent for diabetes and/or complications of diabetes based on the novel mode of action. The protease-inhibiting compound according to the present invention is a compound represented by the general formula (I) [wherein all the symbols have the same meanings as described in the specification], its salt or solvate, or a prodrug thereof, is useful as a preventive and/or therapeutic agent for diabetes and/or complications of diabetes.
• US7671057B2
  申请人：——

  公开号：US7671057B2

  公开（公告）日：2010-03-02