7-Azaspiro[4.5]decan-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 7-Azaspiro[4.5]decan-4-one
• 化学式: C₉H₁₅NO
• 分子量: 153.22
• InChiKey: PIVDIVCGQPBVDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] IMIDAZOPYRIDIN-2-ONE DERIVATIVES<br/>[FR] DÉRIVÉS D'IMIDAZOPYRIDIN-2-ONE
  申请人：MERCK SHARP & DOHME

  公开号：WO2011034741A1

  公开（公告）日：2011-03-24

  The present invention is directed to imidazopyridin-2-one derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

  本发明涉及嘌呤吡啶-2-酮衍生物，它们是代谢型谷氨酸受体的增效剂，特别是mGluR2受体，对治疗或预防与谷氨酸功能障碍相关的神经和精神疾病以及代谢型谷氨酸受体参与的疾病具有用处。该发明还涉及包含这些化合物的药物组合物以及在预防或治疗这些代谢型谷氨酸受体参与的疾病中使用这些化合物和组合物。
• Spiro[cyclopent[b]indole-piperidines]
  申请人：Hoechst Marion Roussel, Inc.

  公开号：US20020004601A1

  公开（公告）日：2002-01-10

  Novel spiro[cyclopent[b]indole-piperidines], intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the spiro[cyclopent[b]indole-piperidines] and intermediates, or compositions thereof are disclosed.

  本发明涉及新型螺环戊烷并吲哚-哌啶衍生物、其中间体和制备方法，以及利用所述螺环戊烷并吲哚-哌啶衍生物及其中间体或组合物缓解记忆功能障碍和治疗抑郁症的方法。
• NOVEL COMPOUNDS
  申请人：Gleave Robert James

  公开号：US20130109711A1

  公开（公告）日：2013-05-02

  The invention relates to novel spirocyclic derivatives with affinity for Cav2.2 calcium channels and which are capable of interfering with Cav2.2 calcium channels; to processes for their preparation; to pharmaceutical compositions containing them; and to the use of such compounds in therapy for the treatment of pain.

  本发明涉及一种具有亲和力的新型螺环衍生物，其可干扰Cav2.2钙通道，并涉及其制备方法，包含它们的制药组合物和这些化合物在治疗疼痛方面的使用。
• SPIROCYCLIC KETONES AND THEIR USE AS TACHYKININ ANTAGONISTS
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP1161419A1

  公开（公告）日：2001-12-12
• Spirocyclic derivatives
  申请人：CHRONOS THERAPEUTICS LIMITED

  公开号：US20170253615A1

  公开（公告）日：2017-09-07

  The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease, disorder or condition ameliorated by inhibition of a dopamine transporter); and methods of treating patients with such compounds; wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 9 , R 10 , Q, X, Y, Z, A, L, B, m, n and p are as defined herein.