4-aza-4-butyl-2,2-dimethyl-1-oxaspiro[4.5]decane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 4-aza-4-butyl-2,2-dimethyl-1-oxaspiro[4.5]decane
• 英文别名: 4-Butyl-2,2-dimethyl-1-oxa-4-azaspiro[4.5]decane
• 化学式: C₁₄H₂₇NO
• 分子量: 225.374
• InChiKey: HOWHAPDRGOUTPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲基环氧丙烷 、 N-cyclohexylidenebutylamine 在 samarium diiodide 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 以82%的产率得到4-aza-4-butyl-2,2-dimethyl-1-oxaspiro[4.5]decane
  参考文献：
  名称：

  Synthesis of 1,3-oxazolidines from imines and epoxides catalyzed by samarium compounds

  摘要：

  A new method for the synthesis of 1,3-oxazolidine derivatives has been developed. Thus, a variety of 1,3-oxazolidines was prepared by the reaction of imines with epoxides in the presence of a catalytic amount of a samarium compound such as SmI2, SmI3, or Cp*Sm-2(thf)(2). (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00374-9

文献信息

• Process for producing 1,3-oxazolidine derivatives
  申请人：Daicel Chemical Industries, Ltd.

  公开号：EP1026161A1

  公开（公告）日：2000-08-09

  A process produces 1,3-oxazolidine derivatives by reacting an imine derivative of the following formula (1): with an epoxy compound of the following formula (2): to yield an oxazolidine derivative of the following formula (3): A compound of Group 3 elements of the Periodic Table of Elements, or other metallic compounds can be used as a catalyst. In the formulae, R1, R2, R4, R5, R6, and R7 are each, independently, a hydrogen atom, a hydrocarbon group, or a heterocyclic group, and R3 is a hydrogen atom, a hydrocarbon group, a heterocyclic group, a hydroxyl group, a substituted oxy group, or an amino group which may have a substituent, where a combination of R1 and R2, R4 and R5, R6 and R7, or R4 and R6 may be combined to form a ring with the adjacent carbon atom or carbon-carbon bond. The process can easily yield 1,3-oxazolidine derivatives from readily available materials.

  一种生产 1,3-噁唑烷衍生物的工艺是将下式（1）的亚胺衍生物与下式（2）的环氧化合物反应： 与下式（2）的环氧化合物反应，生成下式（3）的恶唑烷衍生物： 生成下式（3）的恶唑烷衍生物： 可使用元素周期表中第 3 族元素的化合物或其他金属化合物作为催化剂。式中，R1、R2、R4、R5、R6 和 R7 各自独立地为氢原子、烃基或杂环基，R3 为氢原子、烃基、杂环基、羟基、取代氧基或可能具有取代基的氨基，其中 R1 和 R2、R4 和 R5、R6 和 R7 或 R4 和 R6 的组合可与相邻碳原子或碳-碳键结合形成环。该工艺可以很容易地从现成的材料中得到 1,3-恶唑烷衍生物。
• US6271387B1
  申请人：——

  公开号：US6271387B1

  公开（公告）日：2001-08-07
• Synthesis of 1,3-oxazolidines from imines and epoxides catalyzed by samarium compounds
  作者：Takayuki Nishitani、Hiroyuki Shiraishi、Satoshi Sakaguchi、Yasutaka Ishii

  DOI：10.1016/s0040-4039(00)00374-9

  日期：2000.4

  A new method for the synthesis of 1,3-oxazolidine derivatives has been developed. Thus, a variety of 1,3-oxazolidines was prepared by the reaction of imines with epoxides in the presence of a catalytic amount of a samarium compound such as SmI2, SmI3, or Cp*Sm-2(thf)(2). (C) 2000 Elsevier Science Ltd. All rights reserved.