(3-内)-8-乙酰基-8-氮杂双环[3.2.1]辛烷-3-胺 | 793662-76-7

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 中文名称: (3-内)-8-乙酰基-8-氮杂双环[3.2.1]辛烷-3-胺
• 中文别名: 三氯乙氧基钛
• 英文名称: 1-{3-Amino-8-azabicyclo[3.2.1]octan-8-yl}ethan-1-one
• 英文别名: 1-(3-amino-8-azabicyclo[3.2.1]octan-8-yl)ethanone
• CAS: 793662-76-7
• 化学式: C₉H₁₆N₂O
• 分子量: 168.24
• InChiKey: FBCWQRRMRIKGKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5), PHARMACEUTICAL PRODUCTS THEREOF, AND METHODS THEREOF
  申请人：PHARMABLOCK SCIENCES (NANJING), INC.

  公开号：US20200399261A1

  公开（公告）日：2020-12-24

  The present invention provides PRMT5 inhibitors of Formula (I), wherein R 1 is a non-hydrogen monovalent group; W is a direct bond or —NH—; T, U, and V are independently of each other selected from C and N; R 2 is H or a halo; m is 1 or 2; X is a carbon, a nitrogen, or an oxygen; Y is C or N; Z is a direct bond or a carbon; R 3 is H, a non-hydrogen monovalent group, an oxo group, a bivalent spiro ring-forming group, or a bivalent bridge-forming group; n is 1 or 2; and Formula (II) stands for a single bond or a double bond. Pharmaceutical products comprising the PRMT5 inhibitors and use thereof in treating proliferative disorders such as cancer, metabolic disorders, blood disorders, autoimmune diseases, and inflammatory diseases are also provided.