(3-Amino-2-methylpropyl)-butylphosphinic acid

• 分子结构分类: 有机化合物 - 有机磷化合物
• 英文名称: (3-Amino-2-methylpropyl)-butylphosphinic acid
• 化学式: C₈H₂₀NO₂P
• 分子量: 193.22
• InChiKey: LOMVZWBPPCQLCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Method for Producing Mono-Aminofunctionalized Dialkylphosphinic Acids and Esters and Salts Thereof and Use Thereof
  申请人：Hill Michael

  公开号：US20110213061A1

  公开（公告）日：2011-09-01

  The invention relates to a method for producing mono-aminofunctionalized dialkylphosphinic acids and esters and salts thereof, characterized in that a) a phosphinic acid source (I) is reacted with olefins (IV) to yield an alkylphosphonic acid, salt or ester (II) thereof in the presence of a catalyst A, b) the thus obtained alkylphosphonic acid, salt or ester (II) thereof is reacted with acetylenic compounds of formula (V) to yield a mono-functionalized dialkylphosphinic acid derivative (VI) in the presence of a catalyst B, and c) the thus obtained mono-functionalized dialkylphosphinic acid derivative (VI) is reacted with a hydrogen cyanide source to yield a mono-functionalized dialkylphosphinic acid derivative (VII) in the presence of a catalyst C, and d) the thus obtained mono-functionalized dialkylphosphinic acid derivative (VII); is reacted to yield a mono-aminofunctionalized dialkylphosphinic acid derivative (III) in the presence of a catalyst D or a reduction agent, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 are the same or different and stand independently of each other, among other things, for H, C 1 -C 18 alkyl, C 6 -C 18 aryl, C 6 -C 18 aralkyl, C 6 -C 18 alkylaryl, and X stands for H, C 1 -C 18 alkyl, C 6 -C 18 aryl, C 6 -C 18 aralkyl, C 6 -C 18 alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonized nitrogen base, and Y stands for a mineral acid, a carboxylic acid, a Lewis acid or an organic acid, n=0 to 4 and the catalysts A, B, C and D are formed by transition metals, transition metal compounds and/or catalyst systems composed of a transition metal and/or a transition metal compound and at least one ligand.

  本发明涉及一种生产单氨基功能化二烷基膦酸和酯及其盐的方法，其特征在于：a）在催化剂A的存在下，将膦酸源（I）与烯烃（IV）反应，得到烷基膦酸盐或酯（II）；b）在催化剂B的存在下，将所得的烷基膦酸盐或酯（II）与式（V）的乙炔化合物反应，得到单官能化的二烷基膦酸衍生物（VI）；c）在催化剂C的存在下，将所得的单官能化的二烷基膦酸衍生物（VI）与氰化氢源反应，得到单官能化的二烷基膦酸衍生物（VII）；d）在催化剂D或还原剂的存在下，将所得的单官能化的二烷基膦酸衍生物（VII）反应，得到单氨基功能化的二烷基膦酸衍生物（III）。其中，R1、R2、R3、R4、R5、R6可以相同或不同，独立地代表H、C1-C18烷基、C6-C18芳基、C6-C18芳基烷基、C6-C18烷基芳基，X代表H、C1-C18烷基、C6-C18芳基、C6-C18芳基烷基、C6-C18烷基芳基、Mg、Ca、Al、Sb、Sn、Ge、Ti、Fe、Zr、Zn、Ce、Bi、Sr、Mn、Cu、Ni、Li、Na、K和/或质子化的氮碱基，Y代表矿酸、羧酸、Lewis酸或有机酸，n=0至4，催化剂A、B、C和D由过渡金属、过渡金属化合物和/或由过渡金属和/或过渡金属化合物和至少一种配体组成的催化剂体系形成。
• Method for Producing Mono-Aminofunctionalized Dialkylphosphinic Acids and Esters and Salts Thereof by Means of Acrylnitriles and Use Thereof
  申请人：Hill Michael

  公开号：US20110213078A1

  公开（公告）日：2011-09-01

  The invention relates to a method for producing mono-aminofunctionalized dialkylphosphinic acids and esters and salts thereof by means of acrylnitriles, characterized in that a) a phosphinic acid source (I) is reacted with olefins (IV) to yield an alkylphosphonic acid, salt or ester (II) thereof in the presence of a catalyst A, b) the thus obtained alkylphosphonic acid, salt or ester (II) thereof is reacted with an acrylnitrile of formula (V) to yield a mono-functionalized dialkylphosphinic acid derivative (VI) in the presence of a catalyst B, and c) the thus obtained mono-functionalized dialkylphosphinic acid derivative (VI) is reacted to yield a mono-aminofunctionalized dialkylphosphinic acid derivative (III) in the presence of a catalyst C or a reduction agent, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 are the same or different and stand independently of each other, among other things, for H, C 1 -C 18 alkyl, C 6 -C 18 aryl, C 6 -C 18 aralkyl, C 6 -C 18 alkylaryl and X stands for H, C 1 -C 18 alkyl, C 6 -C 18 aryl, C 6 -C 18 aralkyl, C 6 -C 18 alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonized nitrogen base, and Y stands for a mineral acid, a carboxylic acid, a Lewis acid or an organic acid, n=an integer or fractional number of 0 to 4 and the catalysts A and C are formed by transition metals, transition metal compounds and/or catalyst systems composed of a transition metal and/or a transition metal compound and at least one ligand, and catalyst B is formed by compounds forming peroxides, peroxo compounds, azo compounds, alkali metals, alkaline earth metals, alkali hydrides, alkaline earth hydrides and/or alkali alcoholates and alkaline earth alcoholates.

  本发明涉及一种通过丙烯腈制备单氨基功能化二烷基膦酸和酯及其盐的方法，其特征在于：a）在催化剂A的存在下，将膦酸源（I）与烯烃（IV）反应，得到烷基膦酸盐或酯（II）；b）在催化剂B的存在下，将所得的烷基膦酸盐或酯（II）与式（V）的丙烯腈反应，得到一种单功能化的二烷基膦酸衍生物（VI）；c）在催化剂C或还原剂的存在下，将所得的单功能化的二烷基膦酸衍生物（VI）反应，得到一种单氨基功能化的二烷基膦酸衍生物（III）。其中，R1、R2、R3、R4、R5、R6、R7相同或不同且独立地代表H、C1-C18烷基、C6-C18芳基、C6-C18芳基烷基、C6-C18烷基芳基，X代表H、C1-C18烷基、C6-C18芳基、C6-C18芳基烷基、C6-C18烷基芳基、Mg、Ca、Al、Sb、Sn、Ge、Ti、Fe、Zr、Zn、Ce、Bi、Sr、Mn、Cu、Ni、Li、Na、K和/或质子化氮碱，Y代表矿酸、羧酸、路易斯酸或有机酸，n为0到4的整数或分数，催化剂A和C由过渡金属、过渡金属化合物和/或由过渡金属和/或过渡金属化合物和至少一种配体组成的催化剂体系形成，催化剂B由形成过氧化物、过氧化物化合物、偶氮化合物、碱金属、碱土金属、碱金属氢化物、碱土金属氢化物和/或碱金属醇盐和碱土金属醇盐的化合物组成。
• Method for Producing Monoamino-Functionalised Dialkylphosphinite Acids Esters and Salts and Use Thereof
  申请人：Hill Michael

  公开号：US20110213079A1

  公开（公告）日：2011-09-01

  The invention relates to method for producing mono amino-functionalised dialkylphosphonic acids esters and salts, characterised in that a) a phosphinic acid source (I) is reacted with olefins (IV) in the presence of a catalyst A to give an alkylphosphonous acid, the salt or ester thereof (II), b) the alkylphosphonous acid, the salt or ester thereof (II) produced above is reacted with an allylamine of formula (V) in the presence of a catalyst B to give mono amino-functionalised dialkylphosphinic acid derivatives (III) where, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 independently=amongst others, H, C 1 -C 18 alkyl, C 6 -C 18 aryl, C 6 -C 18 aralkyl, C 6 -C 18 alkylaryl and X═H, C 1 -C 18 alkyl, C 6 -C 18 aryl, C 6 -C 18 aralkyl, C 6 -C 18 alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonated nitrogen base and Y=a mineral acid, a carboxylic acid, a Lewis acid or organic acid, where n=a whole or fractional number from 0 to 4, catalyst A is a transition metal and/or transition metal compound and/or catalyst system comprising a transition metal and/or a transition metal compound and at least one ligand and catalyst B is compounds forming peroxides and/or peroxide compounds and/or azo compounds.

  本发明涉及一种生产单氨基功能化二烷基膦酸酯和盐的方法，其特征在于a)在催化剂A的存在下，将膦酸源(I)与烯烃(IV)反应，得到一种烷基膦酸、其盐或酯(II)，b)将上述生产的烷基膦酸、其盐或酯(II)与式(V)的烯丙胺在催化剂B的存在下反应，得到单氨基功能化二烷基膦酸衍生物(III)，其中，R1、R2、R3、R4、R5、R6、R7、R8、R9独立地等于H、C1-C18烷基、C6-C18芳基、C6-C18芳基烷基、C6-C18烷基芳基和X═H、C1-C18烷基、C6-C18芳基、C6-C18芳基烷基、C6-C18烷基芳基、Mg、Ca、Al、Sb、Sn、Ge、Ti、Fe、Zr、Zn、Ce、Bi、Sr、Mn、Cu、Ni、Li、Na、K和/或质子化氮碱，Y为矿物酸、羧酸、路易斯酸或有机酸，n为0到4的整数或分数，催化剂A为过渡金属和/或过渡金属化合物和/或催化剂体系，包括过渡金属和/或过渡金属化合物和至少一个配体，催化剂B为形成过氧化物和/或过氧化物化合物和/或偶氮化合物的化合物。
• VERFAHREN ZUR HERSTELLUNG VON MONO-AMINOFUNKTIONALISIERTEN DIALKYLPHOPHINSÄUREN, -ESTERN UND -SALZEN UND IHRE VERWENDUNG
  申请人：Clariant International Ltd.

  公开号：EP2352741A1

  公开（公告）日：2011-08-10
• VERFAHREN ZUR HERSTELLUNG VON MONO-AMINOFUNKTIONALISIERTEN DIALKYLPHOSPHINSÄUREN, DEREN SALZE UND ESTER UND IHRE VERWENDUNG
  申请人：Clariant International Ltd.

  公开号：EP2352736A1

  公开（公告）日：2011-08-10