4-(3,3-Dimethylpiperidin-1-yl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: 4-(3,3-Dimethylpiperidin-1-yl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine
• 化学式: C₁₇H₂₃N₃S
• 分子量: 301.5
• InChiKey: JEBHUFMDZLZEJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  57.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• 4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same, and their use in the treatment or prevention of PDE7B-mediated diseases and conditions
  申请人：——

  公开号：US20030119829A1

  公开（公告）日：2003-06-26

  The invention relates to 4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same and their use to treat or prevent diseases and conditions mediated by the phosphodiesterase enzyme 7 B (PDE7 B ). Diseases and conditions mediated by PDE7 B include osteoporosis, osteopenia and asthma.

  该发明涉及4-氨基-5,6-取代噻吩[2,3-d]嘧啶，包含这些化合物的药物组合物以及它们用于治疗或预防由磷酸二酯酶7B（PDE7B）介导的疾病和症状的用途。由PDE7B介导的疾病和症状包括骨质疏松症、骨质疏松症和哮喘。
• NOVEL 4-AMINO-5,6-SUBSTITUTED THIOPHENO 2,3-D]PYRIMIDINES
  申请人：Bayer Corporation

  公开号：EP1401840A1

  公开（公告）日：2004-03-31
• EP1401840A4
  申请人：——

  公开号：EP1401840A4

  公开（公告）日：2007-05-16
• [EN] NOVEL 4-AMINO-5,6-SUBSTITUTED THIOPHENO[2,3-D]PYRIMIDINES<br/>[FR] NOUVEAUX THIOPHENO[2,3-D]PYRIMIDINES 4-AMINO-5,6-SUBSTITUTES
  申请人：BAYER AG

  公开号：WO2002088138A1

  公开（公告）日：2002-11-07

  The invention relates to 4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same and their use to treat or prevent diseases and conditions mediated by the phosphodiesterase enzyme 7B(PDE7B). Diseases and conditions mediated by PDE7B include osteoporosis, osteopenia and asthma.