1,2-苯并异唑-3-甲基苯基磷酸盐 | 94820-31-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 中文名称: 1,2-苯并异唑-3-甲基苯基磷酸盐
• 中文别名: 1,2-苯并异噁唑-3-甲基苯基磷酸盐
• 英文名称: 1,2-benzisoxazol-3-yl diphenyl phosphate
• 英文别名: 1,2-benzisoxazol-3-yl-diphenyl phosphate；Benzo[d]isoxazol-3-yl diphenyl phosphate；1,2-benzoxazol-3-yl diphenyl phosphate
• CAS: 94820-31-2
• 化学式: C₁₉H₁₄NO₅P
• 分子量: 367.298
• InChiKey: JPOAONLOMFVCMC-UHFFFAOYSA-N

物化性质

• 熔点：
  64 °C
• 稳定性/保质期：

  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  70.8
• 氢给体数：
  0
• 氢受体数：
  6

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  1,2-苯并异唑-3-甲基苯基磷酸盐 、 苯甲酸 在 三乙胺 作用下， 以 various solvent(s) 为溶剂， 反应 2.0h， 以98%的产率得到3-(benzoyloxy)-1,2-benzisoxazole
  参考文献：
  名称：

  1,2-Benzisoxazol-3-yl diphenyl phosphate: a new, reactive activating agent for the synthesis of amides, esters, and peptides via condensation

  摘要：

  DOI：

  10.1021/jo00206a006
• 作为产物：
  描述：

  氯磷酸二苯酯 、 苯[D]异恶唑-3-醇 在 三乙胺 作用下， 以 苯 为溶剂， 反应 0.5h， 以82%的产率得到1,2-苯并异唑-3-甲基苯基磷酸盐
  参考文献：
  名称：

  1,2-Benzisoxazol-3-yl diphenyl phosphate: a new, reactive activating agent for the synthesis of amides, esters, and peptides via condensation

  摘要：

  DOI：

  10.1021/jo00206a006
• 作为试剂：
  描述：

  BOC-L-苯丙氨酸 、 甘氨酸乙酯盐酸盐 在 TEA 、 1,2-苯并异唑-3-甲基苯基磷酸盐 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以90%的产率得到ethyl (N-tert-butoxycarbonyl-L-phenylalanyl)glycinate
  参考文献：
  名称：

  1,2-Benzisoxazol-3-yl diphenyl phosphate: a new, reactive activating agent for the synthesis of amides, esters, and peptides via condensation

  摘要：

  DOI：

  10.1021/jo00206a006

文献信息

• PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS
  申请人：Zhou Jiacheng

  公开号：US20100190981A1

  公开（公告）日：2010-07-29

  The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.

  本发明涉及制备手性取代吡唑基吡咯并[2,3-d]嘧啶的公式III的过程，以及相关的合成中间体化合物。这些手性取代吡唑基吡咯并[2,3-d]嘧啶可用作抑制Janus激酶家族蛋白酪氨酸激酶（JAKs）的药物，用于治疗炎症性疾病、骨髓增生性疾病和其他疾病。
• Conjugation Reactions
  申请人：Gee Nicholas

  公开号：US20120237998A1

  公开（公告）日：2012-09-20

  We describe methods that allow either carbodiimides or other carboxyl-reactive substances to be mixed with solutions of carboxylic acids or phosphates or amines or combinations thereof, so as to form a homogeneous mixture which is then dried, preferably in a freeze drying process. The mixture is then contacted with an entity, which preferably involves the dissolution of the mixture with a buffered solution of the entity, so as to initiate a conjugation reaction between the entity and a component in the mixture.

  我们描述了一种方法，可以将肼或其他羧基反应性物质与羧酸或磷酸盐或胺或其组合物的溶液混合，以形成均匀混合物，然后将其干燥，最好使用冷冻干燥过程。然后将混合物与实体接触，最好是通过用实体的缓冲溶液溶解混合物来启动混合物中的组分与实体之间的结合反应。
• Polyphenylene ether-polyester copolymers precursors therefor, compositions containing said copolymers, and methods for their preparation
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0248263A2

  公开（公告）日：1987-12-09

  Compositions containing polyphenylene ether-poly(alkylene dicarboxylate) copolymers are prepared by a reaction between the two polymers and, optionally, at least one functionalizing agent therefor. The functionalizing agent may first be reacted with the polyphenylene ether and the resulting functionalized polyphenylene ether in turn reacted with a functionalized or unfunctionalized poly(alkylene dicarboxylate). Alternatively, an unfunctionalized or hydroxyalkyl-functionalized polyphenylene ether may be incorporated in a conventional polyester-forming reaction. The copolymer-containing compositions are characterized by a number of desirable properties including high impact strength and solvent resistance.

  含有聚苯醚-聚(亚烷基二甲酸酯)共聚物的组合物是通过两种聚合物和至少一种官能化剂的反应制备的。官能化剂可首先与聚苯醚反应，然后将得到的官能化聚苯醚与官能化或未官能化的聚(烷烃二羧酸盐)反应。或者，也可以将未官能化或羟烷基官能化的聚苯醚加入到传统的聚酯形成反应中。含共聚物的组合物具有许多理想的特性，包括高冲击强度和耐溶剂性。
• A method of crosslinking collagen-based material and bioprosthetic devices produced therefrom
  申请人：MEDTRONIC, INC.

  公开号：EP0897942A1

  公开（公告）日：1999-02-24

  Methods of crosslinking collagen-based material having collagen amine groups and collagen carboxyl groups are provided. The methods comprise blocking at least a portion of the collagen amine groups with a blocking agent to form blocked amine groups; contacting the collagen-based material having the blocked amine groups with a polyfunctional spacer; and activating at least a portion of the collagen carboxyl groups after blocking at least a portion of the collagen amine groups, wherein the polyfunctional spacer crosslinks the collagen-based material and wherein said contacting step may be effected before or after said activating step. Bioprosthetic devices made from said crosslinked collagen-based material are also provided.

  提供了交联具有胶原胺基团和胶原羧基的胶原基材料的方法。 这些方法包括用封端剂封端至少一部分胶原胺基团，以形成封端胺基团； 将具有阻断胺基团的胶原基材料与多官能团间隔物接触；以及 在阻断至少一部分胶原胺基团后，激活至少一部分胶原羧基、 其中，多官能团间隔物交联胶原基材料，所述接触步骤可在所述活化步骤之前或之后进行。 还提供了由所述交联胶原基材料制成的生物修复装置。
• A method of making a crosslinked collagen-based material and bioprosthetic devices produced therefrom
  申请人：MEDTRONIC, INC.

  公开号：EP0898973A2

  公开（公告）日：1999-03-03

  A method of making a crosslinked collagen-based material having collagen amine groups and collagen carboxyl groups is provided, the method comprising combining an epoxy functionalized crosslinking agent with the collagen-based material in an aqueous medium at an acidic pH to react a portion of the collagen carboxyl groups with the epoxy functionalized crosslinking agent to form crosslinked collagen-based material comprising residual collagen carboxyl groups. Bioprosthetic devices made from collagen based material according to the invention are also provided.

  本发明提供了一种制造具有胶原胺基团和胶原羧基团的交联胶原基材料的方法，该方法包括在酸性pH值的水介质中将环氧官能化交联剂与胶原基材料结合，使部分胶原羧基团与环氧官能化交联剂反应，形成具有残余胶原羧基团的交联胶原基材料。根据本发明，还提供了由胶原蛋白基材料制成的生物修复装置。