3-[(1E)-3-(4-methoxyphenyl)-3-oxoprop-1-en-1-yl]phenyl 3,4,5-trimethoxybenzoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: 3-[(1E)-3-(4-methoxyphenyl)-3-oxoprop-1-en-1-yl]phenyl 3,4,5-trimethoxybenzoate
• 英文别名: [3-[(E)-3-(4-methoxyphenyl)-3-oxoprop-1-enyl]phenyl] 3,4,5-trimethoxybenzoate
• 化学式: C₂₆H₂₄O₇
• 分子量: 448.5
• InChiKey: UNGBGWHQZCUPIC-MDWZMJQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Novel Use of Organic Compounds
  申请人：D'orazio Daniel

  公开号：US20090239944A1

  公开（公告）日：2009-09-24

  The present invention relates to compounds of the formula I wherein R 3 is C 1-6 -alkyloxy, C 1-6 -acyloxy or aroyloxy; R 6 is hydrogen or C 1-6 -alkyloxy; R 7 is C 1-6 -alkyloxy, C 1-6 -acyloxy, aroyloxy or arylacyloxy; R 8 is hydrogen or C 1-6 -alkyloxy; or R 7 and R 8 form together a group O-L-O with L being (CR 1 R 2 ) n , with R 1 and R 2 being independently from each other hydrogen or C 1-5 -alkyl and n being an integer from 1 to 3; R 10 is hydrogen or N—C 1-4 -acyl, N—C 1-5 -alkyl-x-C x -alkyl with x being an integer from 1 to 5, for use as medicament for the treatment of a disorder connected to impaired glucose metabolism and impaired insulin action such as syndrome X and diabetes type 1 and 2, especially for the treatment of (non-autoimmune) diabetes type 2. The present invention is also directed to dietary compositions such as (fortified) food, beverages, (fortified) feed, food additives, beverage additives, feed additives, clinical nutrition, dietary supplements, functional food, functional feed and nutraceuticals and to pharmaceutical compositions containing such compounds, to methods of treating a disorder connected to impaired glucose metabolism and impaired insulin action in mammals including humans and to the compounds of the formula I themselves. Another object of the present invention is the use of such compounds for the manufacture of a composition for the treatment of a disorder connected to impaired glucose metabolism and impaired insulin action.