镭,同位素的质量226 | 13982-63-3

• 分子结构分类: 无机化合物 - 均相金属化合物 - 均相碱土金属化合物
• 中文名称: 镭,同位素的质量226
• 英文名称: Radium-226
• CAS: 13982-63-3
• 化学式: Ra
• 分子量: 226.02541
• InChiKey: HCWPIIXVSYCSAN-IGMARMGPSA-N

物化性质

• 颜色/状态：
  Brilliant white metal; body-centered cubic structure. /Radium metal/
• 沸点：
  1737 °C /Radium metal/
• 熔点：
  700 °C /Radium metal/
• 密度：
  5.5 g/cu cm /Radium metal/
• 稳定性/保质期：
  Blackens on exposure to air; ...undergoes spontaneous disintegration with formation of radon

计算性质

• 辛醇/水分配系数(LogP)：
  0.0
• 重原子数：
  1
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

ADMET

毒理性

• 致癌性证据

有足够证据表明，在人类中，治疗性注射镭-224会导致骨肉瘤。有足够证据表明，在人类中，摄入镭-226会导致骨肉瘤和鼻旁窦及乳突的癌症。有足够证据表明，在人类中，摄入镭-228会导致骨肉瘤。/镭-224和镭-228/

There is sufficient evidence in humans that therapeutic injection of radium-224 causes bone sarcomas. There is sufficient evidence in humans that ingestion of radium-226 causes bone sarcomas and carcinomas of the paranasal sinuses and mastoid process. There is sufficient evidence in humans that ingestion of radium-228 causes bone sarcomas. /Radium-224 and radium-228/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

混合α粒子发射体（镭-224、镭-226、钍-227、钍-228、钍-230、钍-232、镎-237、钚-238、钚-239（与钚-240一起）、镅-241、锔-244、锎-249和锎-252）在实验动物中具有致癌性的证据是充分的。/镭、钚、镅、锔、锎/

There is sufficient evidence in experimental animals for the carcinogenicity of mixed alpha-particle emitters (radium-224, radium-226, thorium-227, thorium-228, thorium-230, thorium-232, neptunium-237, plutonium-238, plutonium-239 (together with plutonium-240), americium-241, curium-244, californium-249 and californium-252). /Radium, Plutonium, Americium, Curium, Californium/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

碘-131、铯-137、铈-144和镭-228的混合β粒子发射体在实验动物中具有致癌性。/碘、铯、铈、镭/

There is sufficient evidence in experimental animals for the carcinogenicity of mixed beta-particle emitters (iodine-131, cesium-137, cerium-144 and radium-228). /Iodine, Cesium, Cerium, Radium/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

镭-224（224-Ra）及其衰变产物对人类具有致癌性（第1组）。镭-226（226-Ra）及其衰变产物对人类具有致癌性（第1组）。镭-228（228-Ra）及其衰变产物对人类具有致癌性（第1组）。 /镭-224、镭-228/

Radium-224 (224-Ra) and its decay products are carcinogenic to humans (Group 1). Radium-226 (226-Ra) and its decay products are carcinogenic to humans (Group 1). Radium-228 (228-Ra) and its decay products are carcinogenic to humans (Group 1). /Radium-224, radium-228/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌物分类

国际癌症研究机构致癌剂：镭-226及其衰变产物

IARC Carcinogenic Agent:Radium-226 and its decay products

来源:International Agency for Research on Cancer (IARC)

吸收、分配和排泄

吸入：硝酸钷已被证明在通过气管内注射给予大鼠时具有高度溶解性。有报道称，一名意外吸入钷和硫酸钡混合物的人以及一名吸入含钷化合物的未确定物质的人，硝酸钷的溶解度较低。

Inhalation: Radium /nitrate/ has been shown to be highly soluble /when/ ... administered to rats by intratracheal injection. Less solubility was reported in a person who accidentally inhaled a mixture of radium and barium sulfate and in a person who inhaled an unidentified radium-containing compound. /Radium nitrate/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

人体肺部吸入后对元素的吸收：镭，大多数化合物，中等，10分钟（10%），140天（90%）/来自表格/

Absorption of elements in the human lung after inhalation: Radium, most compounds, medium, 10 min (10%), 140 days (90%) /from table/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

摄入：国际放射性辐射防护委员会（ICRP）碱性地球元素代谢成人组审查的平衡研究表明，从食物或饮用水中吸收的镭的比例为0.15-0.21。一项对单一志愿者摄入已知量镭的研究表明，其吸收比例更高，约为0.5，而老年受试者摄入含有224-RaSO4的模拟镭表盘涂料时，平均吸收率约为20%。/镭-224硫酸盐/

Ingestion: Data from balance studies reviewed by the ICRP Task Group on Alkaline Earth Metabolism in Adult Man indicated that the fraction of radium absorbed from food or drinking-water is 0.15-0.21. The results of a study of a single volunteer who ingested a known quantity of radium suggested a higher fractional absorption value of around 0.5, while elderly subjects ingesting mock radium-dial paint containing 224-RaSO4 absorbed an average of about 20%. /Radium-224 sulfate/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

元素在成年人人体内的生物分布：镭，主要沉积部位，骨骼（25%进入血液）；保留半衰期大于或等于20年 /来自表格/

Biodistribution of elements in human adults: Radium, principal deposition sites, skeleton (25% entering blood); retention half-time > or = 20 years /from table/

来源:Hazardous Substances Data Bank (HSDB)