2-(1-氧杂-4-氮杂螺[4.5]癸烷-4-基)乙醇 | 2359-11-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 中文名称: 2-(1-氧杂-4-氮杂螺[4.5]癸烷-4-基)乙醇
• 英文名称: 2-Spirocyclohexyl-3-(β-hydroxyethyl)oxazolidine
• 英文别名: 3-(2-hydroxyethyl)-cyclohexanospiro-2-oxazolidine；4-(2-hydroxyethyl)-1-oxa-4-azaspiro[4.5]decane；N-hydroxyethylencyclohexanespiro-2-oxazolidine；2-(1-oxa-4-aza-spiro[4.5]dec-4-yl)-ethanol；2-(1-Oxa-4-aza-spiro[4.5]dec-4-yl)-aethanol；4-(2-hydroxy-ethyl)-1-oxa-4-aza-spiro(4,5)decane；1-Oxa-4-azaspiro[4.5]decane-4-ethanol；2-(1-oxa-4-azaspiro[4.5]decan-4-yl)ethanol
• CAS: 2359-11-7
• 化学式: C₁₀H₁₉NO₂
• 分子量: 185.266
• InChiKey: DLCNHYLWGIBPPJ-UHFFFAOYSA-N

物化性质

• 密度：
  1.1[at 20℃]

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  2-(1-氧杂-4-氮杂螺[4.5]癸烷-4-基)乙醇 生成 N-phenylcyclohexanespiro-2-oxazolidine
  参考文献：
  名称：

  KUXAREV, B. F.;STANKEVICH, V. K.;KUXAREVA, V. A., XIMIYA GETEROTSIKL. SOEDIN., 1982, N 11, 1560-1561

  摘要：

  DOI：
• 作为产物：
  描述：

  环己酮 、 二乙醇胺 以 苯 为溶剂， 反应 5.0h， 以87%的产率得到2-(1-氧杂-4-氮杂螺[4.5]癸烷-4-基)乙醇
  参考文献：
  名称：

  [有机硫代]乙酸的2-羟基烷基铵盐的合成及生物活性

  摘要：

  ArOC(RtR2)COOR 型芳氧基烷烃羧酸及其衍生物在农业中用作除草剂和植物生长刺激剂 [I]，在医药中用作降胆固醇、降血脂和抗心律失常剂 [2, 3]；它们还表现出抗肿瘤活性 [4]。它们的硫类似物——含有四价和六价硫的（有机硫代）烷烃羧酸及其衍生物——的生物学特性尚未得到广泛研究。已经报道了芳硫基和芳基磺酰乙酸的生长刺激活性 [5, 6]，以及 AlkC6H4CH(SR)COOH 类型的有机硫代取代酸及其酯 [7] 的抗炎和镇痛活性。通式RC(RIR2)COOH的化合物，其中R是未取代或取代的噻吩基-2基团，

  DOI：

  10.1007/bf01150721

文献信息

• Preparation of Delmopinol
  申请人：Comely Alexander

  公开号：US20090036677A1

  公开（公告）日：2009-02-05

  It comprises a preparation process of delmopinol or a pharmaceutically acceptable salt and/or a solvate thereof, by submitting the compound of formula (II) where R 1 and R 2 are the same or different, independently selected from the group consisting of H, (C 1 -C 6 )-alkyl or, alternatively, R 1 and R 2 form, together with the carbon atom to which they are attached, a (C 5 -C 6 )-cycloalkyl radical; and R 3 is a radical selected from the group consisting of CF 3 , (C 1 -C 4 )-alkyl, phenyl, and phenyl mono- or disubstituted by a radical selected from the group consisting of (C 1 -C 4 )-alkyl, halogen and nitro to a deprotection and cyclisation reaction. The process is useful to prepare delmopinol or its salts on an industrial scale. The compound of formula (II) is new and also forms part of the present invention, as well as its preparation process and other new intermediates of said preparation process.

  该发明涉及一种制备德莫匹诺或其药学上可接受的盐和/或其溶剂化物的制备过程，通过将式（II）的化合物提交至去保护和环化反应，其中R1和R2相同或不同，独立地选自H，（C1-C6）-烷基或者，R1和R2与它们连接的碳原子一起形成（C5-C6）-环烷基基团; R3是从CF3，（C1-C4）-烷基，苯基和苯基单取代或双取代基团中选择的基团，所述基团的取代基是从（C1-C4）-烷基，卤素和硝基中选择的基团。该过程有助于在工业规模上制备德莫匹诺或其盐。式（II）的化合物是新的，也是本发明的一部分，以及其制备过程和所述制备过程的其他新中间体。
• Preparation of delmopinol
  申请人：Sinclair Pharmaceuticals Limited

  公开号：US07893258B2

  公开（公告）日：2011-02-22

  It comprises a preparation process of delmopinol or a pharmaceutically acceptable salt and/or a solvate thereof, by submitting the compound of formula (II) where R1 and R2 are the same or different, independently selected from the group consisting of H, (C1-C6)-alkyl or, alternatively, R1 and R2 form, together with the carbon atom to which they are attached, a (C5-C6)-cycloalkyl radical; and R3 is a radical selected from the group consisting of CF3, (C1-C4)-alkyl, phenyl, and phenyl mono- or disubstituted by a radical selected from the group consisting of (C1-C4)-alkyl, halogen and nitro to a deprotection and cyclisation reaction. The process is useful to prepare delmopinol or its salts on an industrial scale. The compound of formula (II) is new and also forms part of the present invention, as well as its preparation process and other new intermediates of said preparation process.

  该方法包括通过将式（II）化合物进行去保护和环化反应来制备delmopinol或其药学上可接受的盐和/或溶剂化物的制备过程，其中R1和R2相同或不同，独立地选自H，（C1-C6）-烷基或者，R1和R2与它们所连接的碳原子一起形成（C5-C6）-环烷基基团；R3是选自CF3，（C1-C4）-烷基，苯基以及苯基单取代或双取代的基团，所述基团选自（C1-C4）-烷基，卤素和硝基。该方法有助于在工业规模下制备delmopinol或其盐。式（II）化合物是新的并且也是本发明的一部分，以及其制备过程和该制备过程的其他新中间体。
• Hydrocurable compositions containing epoxy and oxazolidine or oxazine groups, their use as or in coating and impregnating compositions and polymer containing such groups
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0033515A1

  公开（公告）日：1981-08-12

  Hydrocurable compositions are provided containing a plurality of epoxy groups and oxazolidine or oxazine groups which are storage stable for at least one month under anhydrous conditions. This stability is achieved by selecting oxazolidines or oxazines in which the 2-position carbon atom in the ring is free of hydrogen atoms and substituted by alkyl groups or an alkylene group which forms a hydrocarbon ring with that carbon atom. Upon exposure to moisture the oxa-groups ring open for reaction with the epoxy groups. The groups may be in the same or different components and thus the composition may comprise polyepoxide and a compound or polymer containing a plurality of the oxa-groups or a polymer containing both classes of groups. The latter polymer is one embodiment of the invention. The compositions may be used for coating, impregnating and adhesive purposes.

  本发明提供了含有多个环氧基团和噁唑烷或噁嗪基团的水固化组合物，这些组合物在无水条件下至少可稳定贮存一个月。这种稳定性是通过选择环中 2 位碳原子不含氢原子并被烷基或与该碳原子形成烃环的亚烷基取代的噁唑烷或噁嗪来实现的。当暴露在潮湿环境中时，羰基环会打开，与环氧基团发生反应。这些基团可以是相同或不同的组分，因此组合物可以包括聚环氧化物和含有多个氧杂基团的化合物或聚合物，或含有这两类基团的聚合物。后一种聚合物是本发明的一个实施方案。组合物可用于涂层、浸渍和粘合。
• 2-Hydroxyalkylammonium arylihtoacetates and their effects on the functional activity of thrombocytes
  作者：G. G. Levkovskaya、S. A. Guseva、V. B. Kazimirovskaya、L. N. Kholdeeva、M. G. Voronkov、A. N. Mirskova

  DOI：10.1007/bf00758565

  日期：1986.3
• Bergmann et al., Recueil des Travaux Chimiques des Pays-Bas, 1952, vol. 71, p. 237,239
  作者：Bergmann et al.

  DOI：——

  日期：——