3-(4-Fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: 3-(4-Fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid
• 化学式: C₁₅H₁₈FNO₂
• 分子量: 263.31
• InChiKey: UAVJURKSCUOSRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• METHODS FOR ARRANGING AND PACKING NUCLEIC ACIDS FOR UNUSUAL RESISTANCE TO NUCLEASES AND TARGETED DELIVERY FOR GENE THERAPY
  申请人：The Regents of the University of California

  公开号：US20150190525A1

  公开（公告）日：2015-07-09

  There are disclosed compositions and methods to render nucleic acids resistant to nuclease digestion while maintaining sequence selective hybridization competency. The approach relies on utilizing nucleic acids as the polar head group of a nucleic acid-polymer amphiphile in order to assemble well-defined, discrete micellar nanoparticles. Dense packing of nucleic acid in the micelle corona allows for hybridization of complementary oligonucleotides while prohibiting enzymatic degradation.

  本文披露了一种使核酸在维持序列选择性杂交能力的同时抵抗核酸酶消化的组合物和方法。该方法依赖于利用核酸作为核酸-聚合物两性分子的极性头基，以组装明确定义的离散胶束纳米粒子。在胶束包层中核酸的密集包装允许互补寡核苷酸的杂交，同时禁止酶降解。
• Tropane compounds
  申请人：Blundell Paul

  公开号：US20090208415A1

  公开（公告）日：2009-08-20

  The present invention provides novel tropane compounds and methods for their use.

  本发明提供了新型的托帕替化合物及其使用方法。