1-oxa-3-aza-spiro[4.5]decane-2,4-dione | 7759-32-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 1-oxa-3-aza-spiro[4.5]decane-2,4-dione
• 英文别名: 1-Oxa-3-aza-spiro[4.5]decan-2,4-dion；5,5-Pentamethylenoxazolidin-2,4-dion；5,5-Pentmethylen-oxazolidin-2,4-dion；5,5-Pentandiyl-oxazolidin-2,4-dion；1-Oxa-3-azaspiro[4.5]decane-2,4-dione
• CAS: 7759-32-2
• 化学式: C₈H₁₁NO₃
• 分子量: 169.18
• InChiKey: ZDWSKPIXIMGXQX-UHFFFAOYSA-N

物化性质

• 熔点：
  110-112 °C
• 密度：
  1.27±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-oxa-3-aza-spiro[4.5]decane-2,4-dione 、 三氯硫氯甲烷 生成 3-trichloromethanesulfenyl-1-oxa-3-aza-spiro[4.5]decane-2,4-dione
  参考文献：
  名称：

  一类新的有机杀菌剂。

  摘要：

  DOI：

  10.1126/science.115.2978.84-a
• 作为产物：
  描述：

  1-oxa-3-aza-spiro[4.5]decane-2,4-dione 2-[(1-phenyl-ethylidene)-hydrazone] 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成 1-oxa-3-aza-spiro[4.5]decane-2,4-dione
  参考文献：
  名称：

  Beyer,H.; Spoerl,R., Chemische Berichte, 1966, vol. 99, p. 2719 - 2724

  摘要：

  DOI：

文献信息

• A facile one-pot synthesis of 3-unsubstituted-2,4-oxazolidinediones via in situ generation of carbamates from α-hydroxyesters using trichloroacetyl isocyanate
  作者：Yue H. Li、Li Zhang、Pei-San Tseng、Yongliang Zhang、Yu Jin、Jingkang Shen、Jian Jin

  DOI：10.1016/j.tetlet.2008.11.124

  日期：2009.2

  methodology for the synthesis of pharmaceutically interesting 3-unsubstituted-2,4-oxazolidinediones from α-hydroxyesters is described. A primary carbamate was generated in situ from the corresponding α-hydroxyester and trichloroacetyl isocyanate, then converted to the desired 3-unsubstituted 2,4-oxazolidinedione via intramolecular ring closure. This method is amenable to scale-up and requires no chromatographic

  描述了一种方便，高产率的一锅法，用于从α-羟基酯合成可药用的3-un取代的2,4-恶唑烷二酮。由相应的α-羟基酯和三氯乙酰基异氰酸酯原位生成伯氨基甲酸酯，然后通过分子内闭环将其转化为所需的3-未取代的2,4-恶唑烷二酮。该方法适合扩大规模，无需色谱纯化。
• Study of the Reaction Between Cyanohydrins and Chlorosulfonyl Isocyanate. A New, Efficient Method for the One-Pot Synthesis of 2,4-Oxazolidinediones
  作者：M. Victoria García、J. Carlos Menéndez、Mercedes Villacampa、Mónica M. Söllhuber

  DOI：10.1055/s-1991-26548

  日期：——

  The reaction between cyanohydrins and chlorosulfonyl isocyanate, followed by acid hydrolysis, provides and efficient route for the one-pot preparation of 5,5-disubstituted 2,4-oxazolidinediones.

  氰基卤素与氯磺酰异氰酸酯发生反应，然后进行酸水解，为一次过制备 5,5 二甲基 2,4-oxazolidinediones 提供了有效的途径。
• HALOARYL SUBSTITUTED AMINOPURINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
  申请人：Albers Ronald J.

  公开号：US20090275564A1

  公开（公告）日：2009-11-05

  Provided herein are Aminopurine Compounds having the following structure: wherein R 1 , R 2 and R 3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

  本文提供了具有以下结构的氨基嘌呤化合物：其中R1、R2和R3的定义如本文所述，包含有效量氨基嘌呤化合物的组合物，以及治疗或预防癌症、心血管疾病、肾脏疾病、自身免疫疾病、炎症性疾病、黄斑变性、缺血再灌注损伤、疼痛和相关综合症、与疾病相关的消耗、石棉相关疾病、肺动脉高压或可通过抑制JNK途径治疗或预防的疾病的方法，包括向需要治疗的患者注射有效量的氨基嘌呤化合物。
• Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
  申请人：Albers J. Ronald

  公开号：US20070060598A1

  公开（公告）日：2007-03-15

  Provided herein are Aminopurine Compounds having the following structure: wherein R 1 , R 2 and R 3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

  本文提供了以下结构的氨基嘌呤化合物：其中R1、R2和R3的定义如本文所述，包括有效量的氨基嘌呤化合物的组合物以及治疗或预防癌症、心血管疾病、肾脏疾病、自身免疫疾病、炎症性疾病、黄斑退化、缺血再灌注损伤、疼痛和相关综合征、疾病相关消耗、石棉相关疾病、肺动脉高压或通过给需要治疗或预防JNK通路抑制的患者有效量的氨基嘌呤化合物进行治疗的方法。
• Methods of treatment and prevention using haloaryl substituted aminopurines
  申请人：Bennett L. Brydon

  公开号：US20080021048A1

  公开（公告）日：2008-01-24

  Provided herein are Aminopurine Compounds having the following structure: wherein R 1 , R 2 and R 3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

  本文提供了具有以下结构的氨基嘌呤化合物：其中R1、R2和R3的定义如本文所述，包含有效量的氨基嘌呤化合物的组合物以及用于治疗或预防癌症、心血管疾病、肾脏疾病、自身免疫疾病、炎症性疾病、黄斑变性、缺血再灌注损伤、疼痛和相关综合症、疾病相关消耗、石棉相关疾病、肺动脉高压或通过抑制JNK通路可治疗或预防的疾病的方法，包括向需要治疗的患者施用有效量的氨基嘌呤化合物。

表征谱图