tropane; hydrochloride | 823-42-7

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: tropane; hydrochloride
• 英文别名: Tropan; Hydrochlorid；Tropane, hydrochloride；8-methyl-8-azabicyclo[3.2.1]octane;hydrochloride
• CAS: 823-42-7；823-43-8；23555-06-8
• 化学式: C₈H₁₅N*ClH
• 分子量: 161.675
• InChiKey: PTEBDBUMFCLAAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.05
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  tropane; hydrochloride 生成 降莨菪鹼 、 氯甲烷
  参考文献：
  名称：

  Ladenburg, Chemische Berichte, 1887, vol. 20, p. 1644

  摘要：

  DOI：

文献信息

• INSECT G-COUPLED RECEPTORS USEFUL AS TARGETS FOR INSECTICIDES AND COMPOUNDS AND REAGENTS IDENTIFIED USING THE SAME
  申请人：Purdue Research Foundation

  公开号：US20140350081A1

  公开（公告）日：2014-11-27

  An approach to identify and evaluate potential insecticide targets using publicly available genome (DNA) sequence information for arthropod disease vector is provided. The utility of this approach is demonstrated by first determining the molecular and pharmacological properties of two different dopamine (neurotransmitter) receptors identified in the genome of the yellow fever- and dengue-transmitting mosquito, Aedes aegypti . Next, different chemistries were tested for their ability to interact with one of these dopamine receptors in a chemical compound screen, and “hit” compounds were identified. Finally, it is shown that some of these chemistries, are selective for the mosquito over the human dopamine receptor and that these chemistries caused significant mortality in mosquito larvae 24 hours after exposure.