dimethylaminomethylisopropylsulfide | 77422-33-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫半缩醛胺衍生物
• 英文名称: dimethylaminomethylisopropylsulfide
• 英文别名: 1-(isopropylsulfanyl)-N,N-dimethylmethanamine；(isopropylsulfanyl-methyl)-dimethyl-amine；Dimethylaminomethyl-isopropyl-sulfid；(Isopropylmercapto-methyl)-dimethyl-amin；N,N-dimethyl-1-propan-2-ylsulfanylmethanamine
• CAS: 77422-33-4
• 化学式: C₆H₁₅NS
• 分子量: 133.258
• InChiKey: YIDMWNMGKXPXPG-UHFFFAOYSA-N

物化性质

• 沸点：
  144.8±23.0 °C(Predicted)
• 密度：
  0.893±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  28.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  四甲基甲烷二胺 、 异丙硫醇 以37%的产率得到dimethylaminomethylisopropylsulfide
  参考文献：
  名称：

  Mass spectrometry of organic compounds of the group V Elements: VI—A new type of amine fragmentation under electron impact

  摘要：

  AbstractA new type of amine fragmentation under electron impact is elucidated for proline, sarcosine and aspartic acid derivatives and aminomethylphosphines of the general formula R2NCH2X. Ordinary α‐cleavage affording the \documentclass{article}\pagestyle{empty}\begin{document}$ {\rm R}_2 \mathop {\rm N}\limits^{\rm + } {\rm = CH}_{\rm 2} $\end{document} ion is suppressed by elimination of a neutral HX particle and [M ‐ HX]+ ion formation, or M‐HX neutral particle ejection and generation of an [HX]+ ion from [M]+˙. Such fragmentation is ensured by the presence of an α‐heteroatom (N, O, P, S) in one substituent (X) and a CO2R type delocalizing group in the α‐position of the other substituent (R2N).

  DOI：

  10.1002/oms.1210150804

文献信息

• N,N,N′,N′-tetramethylmethanediamine, efficient reagent for thioles aminomethylation
  作者：R. R. Khairullina、B. F. Akmanov、T. V. Tyumkina、R. V. Kunakova、A. G. Ibragimov

  DOI：10.1134/s1070428012020042

  日期：2012.2

  Efficient method was developed for thiols aminomethylation using N,N,N',N'-tetra-methylmethanediamine in the presence of Sm and Fe salts. Aminosulfides were obtained in high yields and selectivity.
• OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：VARGEESE Chandra

  公开号：US20200157545A1

  公开（公告）日：2020-05-21

  Among other things, the present disclosure provides designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide improved single-stranded RNA interference and/or RNase H-mediated knockdown. Among other things, the present disclosure encompasses the recognition that structural elements of oligonucleotides, such as base sequence, chemical modifications (e.g., modifications of sugar, base, and/or internucleotidic linkages) or patterns thereof, conjugation with additional chemical moieties, and/or stereochemistry [e.g., stereochemistry of backbone chiral centers (chiral internucleotidic linkages)], and/or patterns thereof, can have significant impact on oligonucleotide properties and activities, e.g., RNA interference (RNAi) activity, stability, delivery, etc. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions, for example, in RNA interference and/or RNase H-mediated knockdown.
• [EN] OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF<br/>[FR] COMPOSITIONS D'OLIGONUCLÉOTIDES ET PROCÉDÉS ASSOCIÉS
  申请人：WAVE LIFE SCIENCES LTD

  公开号：WO2017062862A2

  公开（公告）日：2017-04-13

  Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.
• [EN] METHODS AND COMPOSITIONS OF BIOLOGICALLY ACTIVE AGENTS<br/>[FR] PROCÉDÉS ET COMPOSITIONS D'AGENTS BIOLOGIQUEMENT ACTIFS
  申请人：WAVE LIFE SCIENCES LTD

  公开号：WO2017192679A1

  公开（公告）日：2017-11-09

  In some embodiments, the present disclosure pertains to compositions and methods related to delivery of a biologically active agent, wherein the compositions comprise a biologically active agent and a lipid. In various embodiments, the lipid is selected from: lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, alpha-linolenic acid, gamma-linolenic acid, docosahexaenoic acid (cis-DHA), turbinaric acid and dilinoleyl. In some embodiments, a composition and method are useful for delivery of a biologically active agent to a particular cell or tissue, e.g., a muscle cell or tissue.