L-erythritol-4-phosphate | 16409-96-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: L-erythritol-4-phosphate
• 英文别名: phosphoric acid mono-(D-erythro-2,3,4-trihydroxy-butyl ester)；Phosphorsaeure-mono-(D-erythro-2,3,4-trihydroxy-butylester)；D-O¹-Phosphono-erythrit；D-erythritol 1-phosphate；[(2S,3R)-2,3,4-trihydroxybutyl] dihydrogen phosphate
• CAS: 16409-96-4
• 化学式: C₄H₁₁O₇P
• 分子量: 202.101
• InChiKey: QRDCEYBRRFPBMZ-DMTCNVIQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.5
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  127
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  Erythritol 在 recombinant Brucella abortus erythritol kinase 、 5’-三磷酸腺苷 作用下， 以 水 为溶剂， 反应 24.0h， 生成 L-erythritol-4-phosphate
  参考文献：
  名称：

  Functional expression and characterization of eryA, the erythritol kinase of Brucella abortus, and enzymatic synthesis of l-Erythritol-4-phosphate

  摘要：

  The eryA gene of the bacterial pathogen Brucella abortus has been functionally expressed in Escherichia coli. The resultant EryA was shown to catalyze the ATP-dependent conversion of erythritol to L-erythritol-4-phosphate (L-E4P). The steady state kinetic parameters of this reaction were determined and the enzyme as used to prepare L-E4P which was shown to be a weak inhibitor of 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase (YgbP). (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)01032-6

文献信息

• The Enantiomorphic Erythritol 4-Phosphates
  作者：D. L. MacDonald、Hermann O. L. Fischer、Clinton E. Ballou

  DOI：10.1021/ja01596a046

  日期：1956.8
• Functional expression and characterization of eryA, the erythritol kinase of Brucella abortus, and enzymatic synthesis of l-Erythritol-4-phosphate
  作者：Antonietta M Lillo、Charles N Tetzlaff、Félix J Sangari、David E Cane

  DOI：10.1016/s0960-894x(02)01032-6

  日期：2003.2

  The eryA gene of the bacterial pathogen Brucella abortus has been functionally expressed in Escherichia coli. The resultant EryA was shown to catalyze the ATP-dependent conversion of erythritol to L-erythritol-4-phosphate (L-E4P). The steady state kinetic parameters of this reaction were determined and the enzyme as used to prepare L-E4P which was shown to be a weak inhibitor of 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase (YgbP). (C) 2003 Elsevier Science Ltd. All rights reserved.