tert-butyl N-(2-phosphonooxyethyl)carbamate | 932014-80-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: tert-butyl N-(2-phosphonooxyethyl)carbamate
• CAS: 932014-80-7
• 化学式: C₇H₁₆NO₆P
• 分子量: 241.181
• InChiKey: GILBKFCSQYHNTL-UHFFFAOYSA-N

物化性质

• 密度：
  1.325±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  tert-butyl N-(2-phosphonooxyethyl)carbamate 、 farnesyl trichloroacetimidate 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 {2-[Hydroxy-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyloxy)-phosphoryloxy]-ethyl}-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Novel fluorescent analogues for transmembrane movement study of polyprenyl phosphates

  摘要：

  In order to investigate the transmembrane movement of polyprenyl phosphate across biological membranes, NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl)-labeled polyprenyl phosphate analogues were prepared. These analogues proved to be possible tools for a direct observation of the transmembrane flip-flop movement of polyprenyl phosphates by use of a sodium dithionitequenching procedure. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.11.049
• 作为产物：
  描述：

  乙醇胺磷酸酯 、 二碳酸二叔丁酯 在 sodium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 17.0h， 以82%的产率得到tert-butyl N-(2-phosphonooxyethyl)carbamate
  参考文献：
  名称：

  Novel fluorescent analogues for transmembrane movement study of polyprenyl phosphates

  摘要：

  In order to investigate the transmembrane movement of polyprenyl phosphate across biological membranes, NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl)-labeled polyprenyl phosphate analogues were prepared. These analogues proved to be possible tools for a direct observation of the transmembrane flip-flop movement of polyprenyl phosphates by use of a sodium dithionitequenching procedure. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.11.049

文献信息

• [EN] PALMITOYLETHANOLAMIDE COMPOUNDS<br/>[FR] COMPOSÉS DE PALMITOYLÉTHANOLAMIDE
  申请人：TRAVECTA THERAPEUTICS PTE LTD

  公开号：WO2021195555A1

  公开（公告）日：2021-09-30

  The present application provides palmitoylethanolamide compounds useful for treating a disease or disorder in a subject in need thereof. Pharmaceutical compositions comprising the compounds and methods of treating diseases or disorders are also provided.

  本申请提供了对治疗患有疾病或障碍的受试者有用的棕榈醇酰胺化合物。还提供了包含这些化合物的药物组合物以及治疗疾病或障碍的方法。
• [EN] ANANDAMIDE COMPOUNDS<br/>[FR] COMPOSÉS D'ANANDAMIDE
  申请人：TRAVECTA THERAPEUTICS INC

  公开号：WO2020146771A1

  公开（公告）日：2020-07-16

  The present application provides anandamide and 2-arachidonyl glycerol compounds useful for treating a disease or disorder in a subject in need thereof. Pharmaceutical compositions comprising the compounds and methods of treating diseases or disorders are also provided.

  本申请提供了用于治疗患有疾病或紊乱的受试者的阿南胺和2-花生二酰甘油化合物。还提供了包含这些化合物的药物组合物以及治疗疾病或紊乱的方法。
• [EN] IDEBENONE COMPOUNDS<br/>[FR] COMPOSÉS D'IDÉBÉNONE
  申请人：TRAVECTA THERAPEUTICS PTE LTD

  公开号：WO2021211436A1

  公开（公告）日：2021-10-21

  The present application provides idebenone derivatives or analogues useful for treating a disease or disorder in a subject in need thereof. Pharmaceutical compositions comprising the compounds and methods of treating the disease or disorder are also provided.

  本申请提供了对治疗患有疾病或疾病的主体有用的异戊醌衍生物或类似物。还提供了包含这些化合物的药物组合物以及治疗该疾病或疾病的方法。
• [EN] OLEOYLETHANOLAMIDE COMPOUNDS<br/>[FR] COMPOSÉS D'OLÉOYLÉTHANOLAMIDE
  申请人：TRAVECTA THERAPEUTICS PTE LTD

  公开号：WO2021195548A1

  公开（公告）日：2021-09-30

  The present application provides oleoylethanolamide compounds useful for treating a disease or disorder in a subject in need thereof. Pharmaceutical compositions comprising the compounds and methods of treating diseases or disorders are also provided.

  本申请提供了一种对需要的受试者治疗疾病或紊乱有用的油酰乙醇胺化合物。还提供了包含这些化合物的药物组合物以及治疗疾病或紊乱的方法。
• AMINO-METHYL PIPERIDINE DERIVATIVE AS KINASE INHIBITOR
  申请人：Daewoong Pharmaceutical Co., Ltd.

  公开号：EP3733674A1

  公开（公告）日：2020-11-04

  The present invention relates to a compound represented by the following Chemical Formula 1, or a pharmaceutically acceptable salt thereof, and the compound according to the present invention can be usefully used for the prevention or treatment of diseases which are associated with kinase inhibitory actions.

  本发明涉及一种由下化学式 1 表示的化合物或其药学上可接受的盐，根据本发明的化合物可有效地用于预防或治疗与激酶抑制作用有关的疾病。