13-[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]oxy-12,14-dioxa-13lambda5-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaene 13-oxide | 180581-30-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: 13-[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]oxy-12,14-dioxa-13lambda5-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaene 13-oxide
• 英文别名: 13-[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]oxy-12,14-dioxa-13λ5-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaene 13-oxide
• CAS: 180581-30-0
• 化学式: C₃₀H₃₁O₄P
• 分子量: 486.548
• InChiKey: ILNDRNPLRNSGRF-FPUALCIBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  35
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  13-[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]oxy-12,14-dioxa-13lambda5-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaene 13-oxide 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以81%的产率得到(S)-(-)-2,2'-dihydroxy-1,1'-binaphthalene
  参考文献：
  名称：

  A new and efficient method for the resolution of 1,1'-binaphthalene-2,2'-diol

  摘要：

  DOI：

  10.1021/jo00077a072
• 作为产物：
  描述：

  4-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalene 在 叔丁基过氧化氢 作用下， 以 二氯甲烷 为溶剂， 生成 13-[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]oxy-12,14-dioxa-13lambda5-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaene 13-oxide
  参考文献：
  名称：

  On the use of seven-membered phosphorous heterocycles based on 2,2′-dihydroxy-1,1′-binaphthalene and 1,4∶3,6-dianhydro-d-mannitol in the31P NMR analysis of the enantiomeric composition of chiral alcohols

  摘要：

  Some aspects of phosphorylation of 2,2'-dihydroxy-1,1'-binaphthalene (BINOL) and 1,4:3,6-dianhydro-D-mannitol (isomannide) were investigated. The possibility of using the corresponding cyclic chloro-and amidophosphites for the analysis of enantiomeric compositions of chiral primary and secondary alcohols by P-31 NMR was examined.

  DOI：

  10.1007/bf02495644

文献信息

• Fluoride-ion-mediated Hydrolysis of Phosphoric Acid Esters, Amides, and Phosphorous Acid Esters Leading to Phosphorofluoridic, Phosphoramide Fluoridic, and Phosphonic Acid Monoester Salts
  作者：Toshiaki Murai、Tohru Takenaka、Shinsuke Inaji、Yusuke Tonomura

  DOI：10.1246/cl.2008.1198

  日期：2008.12.5

  Fluoride-ion-promoted hydrolysis of phosphoric acid esters and amides to give phosphorofluoridic and phosphoramide fluoridic acid monoester salts takes place upon treatment with a THF solution of T...

  在用 THF 的 THF 溶液处理后，氟离子促进磷酸酯和酰胺水解生成氟代磷酸酯和磷酰胺氟酸单酯盐。
• Direct chirality determination of secondary carbinol by chirality recognition ability of C2 symmetry 1,1'-binaphthyl-2,2'-diyl phosphoryl chloride
  作者：Natsuki Kato

  DOI：10.1021/ja00157a039

  日期：1990.1