Phosphoric acid bis-(4-isopropyl-phenyl) ester phenyl ester | 55864-07-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Phosphoric acid bis-(4-isopropyl-phenyl) ester phenyl ester
• 英文别名: Bis(4-isopropylphenyl) phenyl phosphate；phenyl bis(4-propan-2-ylphenyl) phosphate
• CAS: 55864-07-8
• 化学式: C₂₄H₂₇O₄P
• 分子量: 410.45
• InChiKey: GQJZORIDXGBCCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-异丙基苯酚 、 二氯磷酸苯酯 生成 Phosphoric acid bis-(4-isopropyl-phenyl) ester phenyl ester
  参考文献：
  名称：

  Effects of triaryl phosphates on mouse and human nuclear receptors

  摘要：

  The constitutively active receptor (CAR) is a crucial regulator of genes encoding for enzymes active in drug/steroid oxidation, conjugation, and transport. In our attempt to isolate the endogenous inhibitory ligand(s) for the mouse CAR, we found surprisingly that the inhibitory activity was associated with di- and tri-isopropylated phenyl phosphates that were present in livers of untreated mice. Transactivation experiments in mammalian cells with synthetic compounds verified that mouse CAR was inhibited by various isopropylated phenyl phosphates (40-80%). Such triaryl phosphates are widely used as fire retardants, lubricants, and plasticizers, and some of them are known to disturb reproduction by currently unknown mechanisms. Equipped with the finding that these compounds could interact with mouse CAR, we proceeded to determine their functional effects on other nuclear receptors. Human CAR and pregnane X receptor (PXR) were variably activated (2-5-fold) by triaryl phosphates while mouse PXR, peroxisome proliferator-activated receptor-alpha, and vitamin D receptor were refractory. Among steroid hormone receptors, the human androgen receptor was inhibited by triphenyl phosphate and di-ortho-isopropylated phenyl phosphate (40-50%) and activated by di- and tri-para-substituted phenyl phosphates (2-fold). Our results add to the list of CAR and PXR activators and suggest steroid-dependent biological pathways that may contribute to the reproductive effects of triaryl phosphates. (C) 2003 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bcp.2003.08.037

文献信息

• Low Triphenylphosphate, High Phosphorous Content Isopropyl Phenyl Phosphates With High Ortho Alkylation
  申请人：Layman William J.

  公开号：US20120004438A1

  公开（公告）日：2012-01-05

  The present invention relates to low triphenyl phosphate, high phosphorous content aryl phosphates with high ortho alkylation that are suitable for use as flame retardant compositions, processes for their preparation, and their use as flame retardants.

  本发明涉及低三苯基磷酸酯、高磷含量芳基磷酸酯，具有高度正位烷基化，适用于用作阻燃剂组合物，以及其制备过程和用作阻燃剂的用途。
• ANTI-WEAR AGENTS WITH A REDUCED NEUROTOXICITY
  申请人：Frapin Pascal

  公开号：US20120101015A1

  公开（公告）日：2012-04-26

  Described is a lubricating composition of an anti-wear agent or a combination of anti-wear agents having a reduced neurotoxicity, the anti-wear agent(s) being selected from triaryl phosphate compounds preferably substituted with one or more linear or branched alkyl group(s) including from 2 to 12 carbon atoms.

  描述了一种具有降低神经毒性的抗磨剂或抗磨剂组合的润滑组合物，所述抗磨剂被选择自三芳基磷酸酯化合物，最好是取代有一个或多个线性或支链烷基基团（包括2至12个碳原子）的化合物。
• Flame-retardant organic phosphates, their production, and compositions containing them
  申请人：FMC Corporation

  公开号：EP0005053A2

  公开（公告）日：1979-10-31

  This invention relates to flame-retardant polymeric alkyl aryl phosphates prepared by Friedel-Crafts condensation. The polymeric alkyl aryl phosphates may be made by Friedel-Crafts condensation of chloroalkyl aryl phosphates and alkenyl aryl phosphates derived therefrom. Alernatively, the polymeric alkyl aryl phosphates may be made by Friedel-Crafts condensation of phenols followed by phosphorylation of the Friedel-Crafts condensate. The flame-retardant polymeric alkyl aryl phosphates of the present invention are particularly suitable for use as an additive, having little or no plasticizing effect in flammable organic plastics.

  本发明涉及通过 Friedel-Crafts 缩合法制备的阻燃性聚合烷基芳基磷酸盐。 聚合烷基芳基磷酸盐可以通过氯烷基芳基磷酸盐和由此衍生的烯基芳基磷酸盐的 Friedel-Crafts 缩合法制备。 另外，聚合烷基芳基磷酸盐也可以通过苯酚的 Friedel-Crafts 缩合法，然后对 Friedel-Crafts 缩合物进行磷化处理来制备。 本发明的阻燃性聚合烷基芳基磷酸盐特别适合用作添加剂，在易燃有机塑料中几乎没有增塑作用。
• Fire resistant fluids
  申请人：MOBIL OIL CORPORATION

  公开号：EP0014547A1

  公开（公告）日：1980-08-20

  Fluids based on phosphoric acid esters, or mixtures thereof, containing a corrosion and hydrolysis inhibitor, are useful fire resistant materials.

  以磷酸酯或其混合物为基础、含有腐蚀和水解抑制剂的液体是有用的防火材料。
• Thermoplastic polycarbonate composition
  申请人：DAICEL CHEMICAL INDUSTRIES, LTD.

  公开号：EP0816433A2

  公开（公告）日：1998-01-07

  The present invention aims at modifying a polyblend mainly comprising a polycarbonate resin and a polystyrene resin into a thermoplastic resin composition having flowability and impact strength equivalent to those of a polyblend comprising a polycarbonate resin and an ABS resin, and at providing a harmless flame-retardant thermoplastic resin composition based on the resulting modified composition. Specifically, the present invention relates to a thermoplastic resin comprising 100 parts by weight of a resin mixture comprising 30 to 95% by weight of a polycarbonate resin (a), 5 to 70% by weight of a polystyrene resin (b), 0.5 to 20 parts by weight of a specific block copolymer (c) and, if necessary, 0.1 to 20 parts by weight of a polyalkylene terephthalate (d), and/or 0.1 to 20 parts by weight of a polyphenylene ether resin (e), and a flame-retardant thermoplastic resin composition prepared by blending the above composition with 1 to 40 parts by weight of an organophosphorus compound (f) and, if necessary, 0.05 to 5 parts by weight of a fluoroethylene polymer (g).

  本发明旨在将主要由聚碳酸酯树脂和聚苯乙烯树脂组成的混合物改性为热塑性树脂组合 物，其流动性和冲击强度相当于由聚碳酸酯树脂和 ABS 树脂组成的混合物的流动性和冲击强 度，并提供一种基于所得改性组合物的无害阻燃热塑性树脂组合物。具体地说，本发明涉及一种热塑性树脂，它包含 100 重量份的树脂混合物，其中 30% 至 95% 的聚碳酸酯树脂 (a)，5% 至 70% 的聚苯乙烯树脂 (b)，0.5% 至 20 重量份的特定嵌段共聚物 (c)，以及必要时 0.1 至 20 份（按重量计）的聚对苯二甲酸乙二醇酯（d），和/或 0.1 至 20 份（按重量计）的聚苯醚树脂（e），以及将上述组合物与 1 至 40 份（按重量计）的有机磷化合物（f）和（如有必要）0.05 至 5 份（按重量计）的氟乙烯聚合物（g）混合而制备的阻燃热塑性树脂组合物。