2-(4-phenyldiazenylanilino)acetic acid | 143338-04-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 英文名称: 2-(4-phenyldiazenylanilino)acetic acid
• 英文别名: N-[4-(2-phenyldiazenyl)phenyl]glycine；N-(4-phenylazo-phenyl)-glycine；N-(4-Phenylazo-phenyl)-glycin；(4-Amino-azobenzol)-N-essigsaeure；4-Benzolazo-anilinoessigsaeure；N-(4-Benzolazo-phenyl)-glycin
• CAS: 143338-04-9
• 化学式: C₁₄H₁₃N₃O₂
• 分子量: 255.276
• InChiKey: AVWVEYXVOGAPLJ-WUKNDPDISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  74.05
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  苯胺 在 盐酸 、 水 、 sodium acetate 作用下， 生成 2-(4-phenyldiazenylanilino)acetic acid
  参考文献：
  名称：

  Mai, Chemische Berichte, 1902, vol. 35, p. 580

  摘要：

  DOI：

文献信息

• Spectral and electrochemical solvatochromic investigations of newly synthesized peptide-based chemosensor bearing azobenzene side chain bio photoswitch
  作者：Petar Todorov、Stela Georgieva、Petia Peneva、Jana Tchekalarova

  DOI：10.1016/j.dyepig.2021.109348

  日期：2021.7

  the fluorescence peak and intensity are significantly distinguished in acidic and neutral medium. The electrochemical behavior before and after 90 min UV illumination was investigated using a cyclic voltammetric mode at three-electrode system with HMDE electrode as the working electrode. The novel biopeptide Azo-Tyr-Pro-Trp-Thr-NH2 was explored in vivo for potential anticonvulsant activity by 6-Hz seizure

  在本研究中，已合成并研究了一种新型的含偶氮苯的hemorphin-4类似物，并对其进行了光谱，电化学和生物效应评估。合成是通过Fmoc-strategy通过改良的固相肽合成（SPPS）实现的。该化合物代表了一种新合成且尚未研究的基于肽的化学传感器，带有在两个反式/顺式中具有不同光谱和电化学性质的偶氮苯侧​​链-状态取决于溶剂的极性。发现它们的荧光强度以及伏安行为取决于溶剂的极性和偶氮肽化合物异构体的类型。两种异构体形式均显示出pH依赖性，因为在酸性和中性介质中荧光峰和强度均得到明显区分。使用循环伏安模式在以HMDE电极作为工作电极的三电极系统上研究了90分钟紫外线照射前后的电化学行为。 在体内探索了新型生物肽Azo-Tyr-Pro-Trp-Thr-NH 2ICR小鼠的6 Hz癫痫发作试验和最大电击试验（MES）检测潜在的抗惊厥活性。在最大电击试验中，顺式-Az-H4异构体对6 Hz诱发的精
• TWO-DIMENSIONAL STRUCTURES FROM PEPTOID OLIGOMERS AND METHODS OF MAKING
  申请人：BATTELLE MEMORIAL INSTITUTE

  公开号：US20180215792A1

  公开（公告）日：2018-08-02

  Materials and methods for forming self-assembled peptoid structures that are extremely stable, crystalline, free-standing and self-repairing are described. Based on the peptoid design, peptoid membranes in a 2D arrangement was able toroll into single-walled nanotubes with tunable sizes, diameters, thicknesses and stiffnesses as well as tailorable functions result. Crystalline nanomaterials made through this facile solution crystallization and anisotropic formation process are highly tailorable and exhibit a number of properties advantageous for applications such as water decontamination, cellular adhesion, imaging, surface coating, biosensing, energy conversion, biocatalysis or other applications.
• MULTI-DIMENSIONAL STRUCTURES FROM PEPTOID OLIGOMERS AND METHODS OF MAKING
  申请人：BATTELLE MEMORIAL INSTITUTE

  公开号：US20190262275A1

  公开（公告）日：2019-08-29

  Materials and methods are described for forming self-assembled peptoid structures that are extremely stable, crystalline, free-standing and self-repairing are described. Based on the peptoid design, peptoid membranes in a 2D arrangement were able to roll into single-walled nanotubes with tunable sizes, diameters, thicknesses and stiffnesses as well as tailorable functions result. Crystalline nanomaterials made through this facile solution crystallization and anisotropic formation process are highly tailorable and exhibit a number of properties advantageous for applications such as water decontamination, cellular adhesion, imaging, surface coating, biosensing, energy conversion, biocatalysis or other applications.
• Mai, Chemische Berichte, 1902, vol. 35, p. 580
  作者：Mai

  DOI：——

  日期：——