2-羟基-4-甲氧基-3,6-二甲基-苯甲酸 4-羧基-3-羟基-5-甲基苯基酯 | 500-37-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 中文名称: 2-羟基-4-甲氧基-3,6-二甲基-苯甲酸 4-羧基-3-羟基-5-甲基苯基酯
• 中文别名: 2-羟基-4-甲氧基-3,6-二甲基-苯甲酸4-羧基-3-羟基-5-甲基苯基酯
• 英文名称: Obtusatsaeure
• 英文别名: Ramalic acid；2-hydroxy-4-(2-hydroxy-4-methoxy-3,6-dimethylbenzoyl)oxy-6-methylbenzoic acid
• CAS: 500-37-8
• 化学式: C₁₈H₁₈O₇
• 分子量: 346.337
• InChiKey: GEZCJRBINSDUSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  7

安全信息

• 海关编码：
  2918990090

反应信息

• 作为反应物：
  描述：

  2-羟基-4-甲氧基-3,6-二甲基-苯甲酸 4-羧基-3-羟基-5-甲基苯基酯 在 氢氧化钾 作用下， 生成 2-hydroxy-4-methoxy-3,6-dimethylbenzoic acid
  参考文献：
  名称：

  Pfau, Helvetica Chimica Acta, 1928, vol. 11, p. 873

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 作用下， 生成 2-羟基-4-甲氧基-3,6-二甲基-苯甲酸 4-羧基-3-羟基-5-甲基苯基酯
  参考文献：
  名称：

  Fujikawa, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1936, vol. 56, p. 237,245; dtsch. Ref. S. 25, 27

  摘要：

  DOI：

文献信息

• Asahina; Fujikawa, Chemische Berichte, 1932, vol. 65, p. 580,582
  作者：Asahina、Fujikawa

  DOI：——

  日期：——
• Nakao, Chemical Abstracts, 1923, vol. 17, p. 3184
  作者：Nakao

  DOI：——

  日期：——
• Nakao, Chemisches Zentralblatt, 1925, vol. 96, # II, p. 1769
  作者：Nakao

  DOI：——

  日期：——
• Acupressure wristbands do not prevent postoperative nausea and vomiting after urological endoscopic surgery
  作者：Anil Agarwal、Ashish Pathak、Atul Gaur

  DOI：10.1007/bf03020945

  日期：2000.4

  Purpose: To evaluate the efficacy of acupressure wristbands in the prevention of postoperative nausea and vomiting (PONV).Methods: Two hundred ASA I - II patients undergoing elective endoscopic urological procedures were included in a randomized, prospective, double blind, placebo-controlled study. Spherical beads of acupressure wristbands were placed at the P6 points in the anterior surface of both forearms in Group I patients (acupressure group, n = 100) whereas, in Group 2 (control group, n = 100) they were placed inappropriately on the posterior surface; The acupressure wristbands were applied 30 min before induction of anesthesia and were removed six hours postoperatively, Anesthesia was induced with thiopental and maintained with nitrous oxide and oxygen, fentanyl, isoflurane and vecuronium. The tracheas were extubated on the operation table after patients received neostigmine and atropine. Post operative nausea-and vomiting were evaluated separately as none, mild, moderate or severe at the time of patient's arrival in PACU, then at six hours and twenty-four hours after surgery by a blinded observer.Results: In the acupressure group, 25 patients had PONV compared with 29 patients in the control group (P = NS).Conclusion: Application of acupressure wristbands at the P6 of both forearms 30 min before induction of anesthesia did not decrease the incidence of PONV in patients undergoing endoscopic urological procedures.
• Self-ordered CdSe quantum dots in ZnSe and (Zn, Mn)Se Matrices Assessed by transmission electron microscopy and photoluminescence spectroscopy
  作者：P. Möck、T. Topuria、N. D. Browning、L. Titova、M. Dobrowolska、S. Lee、J. K. Furdyna

  DOI：10.1007/bf02665867

  日期：2001.6

  Single and multilayer sheets of self-assembled CdSe [quantum dots (QDs)] were grown by means of molecular beam epitaxy in both ZnSe and (Zn0.9Mn0.1)Se matrices. Both types of structures were assessed by means of transmission electron microscopy in the scanning, high-resolution, and diffraction-contrast modes. Complementary results from wider sample areas were obtained by means of photoluminescence spectroscopy. In one of the samples analyzed, a fractional monolayer of MnSe was deposited immediately before the CdSe deposition. A second structure grown underidentical conditions, but without the MnSe fractional monolayer, was also analyzed. This comparison provides direct evidence for an enhanced size and shape homogeneity of 3D QDs caused by the presence of a tiny amount of MnSe at the interface. In the multilayer structure, we observed the co-existence of highly strained quasi-2D QDs and CdSe rich aggregates with compositional modulations on certain crystallographic planes in close proximity.