sulfasalazine | 718613-03-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 英文名称: sulfasalazine
• 英文别名: H2SSZ；2-Hydroxy-4-[(E)-{4-[(pyridin-2-yl)sulfamoyl]phenyl}diazenyl]benzoic acid；2-hydroxy-4-[[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl]benzoic acid
• CAS: 718613-03-7
• 化学式: C₁₈H₁₄N₄O₅S
• 分子量: 398.399
• InChiKey: GTTWYCNVHRAJHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  150
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  iron(III) chloride hexahydrate 、 sulfasalazine 以 乙醇 、 氨 为溶剂， 以85%的产率得到FeCl(sulfasalazine)(H2O)3*2H2O
  参考文献：
  名称：

  Synthesis, Spectroscopic and Thermal Characterization of New Sulfasalazine Metal Complexes

  摘要：

  The complexes of Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) with sulfasalazine (H3L) were studied in the solution and in the solid states. The stability constants of the metal complexes were calculated pH-metrically. The solid products were isolated and characterized by elemental, i.r, molar conductance, magnetic moment, diffused reflectance and thermal analyses. The mono- and biscomplexes were isolated with the formula [M(L)(H2O)(n)] mH(2)O and [M(HL)(2)(H2O)n] mH(2)O, respectively, where H2L is sulfasalazine, n = 0,2 or 3, m = 0,1,2,3 or 4 and M = Co, Ni, Cu, Zn and Cd. The mono- and bis-iron(III) complexes were found to have the formulae [M(L) Cl(H2O)(3)] center dot 2H(2)O and [M(HL)(2)Cl(H2O)] center dot H2O, respectively.

  DOI：

  10.1081/sim-200067043

文献信息

• Structural and thermal characterization of cerium, thorium and uranyl complexes of sulfasalazine
  作者：Gehad G. Mohamed、Ahmed A. Soliman、Mohamed A. El-Mawgood

  DOI：10.1016/j.saa.2005.04.006

  日期：2005.12

  Cerium(IV), Thorium(IV) and Uranyl(II) complexes with the ammonium salt of sulfasalazine drug (H2SSZ, HL-) have been studied. The structures of the complexes were elucidated using elemental analysis, IR and mass spectroscopy and thermal analysis. The complexes were isolated in 1:1 and 1:2 (M:L) ratios. The solid monocomplexes (1:1) (M:H(2)SSZ) were isolated in the general formulae [UO2(L)(H2O)2].2H2O and

  研究了铈（IV），Thor（IV）和铀酰（II）与柳氮磺胺吡啶药物（H2SSZ，HL-）的铵盐的配合物。使用元素分析，IR和质谱以及热分析阐明了配合物的结构。以1：1和1：2（M：L）的比例分离复合物。固态单络合物（1：1）（M：H（2）SSZ）以通式[UO2（L）（H2O）2] .2H2O和[M（L）（X）z（H2O）n]分离yH 2 O（M ＝ Ce​​（IV）和Th（IV）（X ＝ NO 3，z ＝ 2，n ＝ 2，y ＝ 0-3））。发现具有以下通式的双络合物（1：2）（M：H2SSZ）固体螯合物[UO2（HL）2] .2H2O和[M（L）2（H2O）2]（M = Ce（IV）和Th （IV））。应讨论与结构有关的配合物的热分解，并使用Coats-Redfern和Horwitz-Mitzger方法评估分解阶段的热力学参数。
• Synthesis, Spectroscopic and Thermal Characterization of New Sulfasalazine Metal Complexes
  作者：Ahmed A. Soliman、Gehad G. Mohamed、Wafaa M. Hosny、Mohamed A. El-Mawgood

  DOI：10.1081/sim-200067043

  日期：2005.7.1

  The complexes of Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) with sulfasalazine (H3L) were studied in the solution and in the solid states. The stability constants of the metal complexes were calculated pH-metrically. The solid products were isolated and characterized by elemental, i.r, molar conductance, magnetic moment, diffused reflectance and thermal analyses. The mono- and biscomplexes were isolated with the formula [M(L)(H2O)(n)] mH(2)O and [M(HL)(2)(H2O)n] mH(2)O, respectively, where H2L is sulfasalazine, n = 0,2 or 3, m = 0,1,2,3 or 4 and M = Co, Ni, Cu, Zn and Cd. The mono- and bis-iron(III) complexes were found to have the formulae [M(L) Cl(H2O)(3)] center dot 2H(2)O and [M(HL)(2)Cl(H2O)] center dot H2O, respectively.