Carbon monoxide;chromium;ethyl azepine-1-carboxylate | 63139-60-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吖庚因类
• 英文名称: Carbon monoxide;chromium;ethyl azepine-1-carboxylate
• CAS: 63139-60-6
• 化学式: C₁₂H₁₁CrNO₅
• 分子量: 301.219
• InChiKey: IAAUMCQBQFBTFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.93
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  32.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Carbon monoxide;chromium;ethyl azepine-1-carboxylate 、 二(三甲基甲硅烷基)乙炔 以 正己烷 为溶剂， 以87%的产率得到tricarbonyl(η(2:4)-7,8-bis(trimethylsilyl)-9-carbethoxy-9-azabicyclo[4.2.1]nona-2,4,7-triene)chromium(0)
  参考文献：
  名称：

  Nucleophilic addition reactions of bridged triene η⁶-chromiumtricarbonyl complexes

  摘要：

  首次证明了金属介导的一系列亲核物与几种桥接δ-6-铬三羰基络合物的加成反应。该反应以区域和立体选择性方式进行，收率相当高。新反应被用于合成锐毒毒素-a 的高级中间体。

  DOI：

  10.1039/b207708f

文献信息

• Metal-Mediated [6 + 2] Cycloadditions of Alkynes to Cycloheptatriene and N-Carbethoxyazepine
  作者：Karen Chaffee、Pei Huo、John B. Sheridan、Anthony Barbieri、Arnis Aistars、Roger A. Lalancette、Robert L. Ostrander、Arnold L. Rheingold

  DOI：10.1021/ja00112a005

  日期：1995.2

  UV photolysis of [(eta(6)-C(7)H(7)R)Cr(Co)(3)] (1, R = H, Ph, CH(CO(2)Me)(2)) and R'C = CR' (R' = Ph, Tol, SiMe(3), Et) in toluene or n-hexane gives the [6 + 2] cycloadducts [(eta(2:4)-C9H7(R)R'(2))Cr(CO)(3)] (2). Heating 2 in toluene releases the 7,8-disubstituted bicyclo[4.2.1]nona-2,4,7-trienes 3 and [(eta(6)-C(6)H(5)Me)Cr(CO)(3)]. Irradiation of solutions of 1 and dimethyl acetylenedicarboxylate at 0 degrees C yields the bicyclotriene as the major product but no organometallic complex. The diphenyl derivative 2a undergoes a reversible intramolecular metal migration to the eta(6)-aryl species 4. Irradiation of the azepine complex [(eta(6)-C6H6N(CO(2)Et))Cr(CO)(3)] (5) and R'C = CR' (R' = Ph, SiMe(3)) in toluene also forms [6 + 2] cycloadducts [(eta(2:4)-C8H6N(CO2Er)R'(2))Cr(CO)(3)] (6). The heterobicyclotrienes 7 are isolated from 6 by treatment with iodine (R' = SiMe(3)) or by hearing in toluene (R' = Ph). X-ray crystal structures are reported for 6b (R' = SiMe(3)) [orthorhombic, P2(1)2(1)2(1), a = 8.871(1), b = 10.148(1), and c = 26.017(4) Angstrom, R = 0.041 for 2500 independent reflections] and a byproduct (8) that results from the endo [6 + 4] cycloaddition of N-carbethoxyazepine to 5; monoclinic, P2(1)/c, a = 10.665(9), b = 14.976(7), and c = 13.004(7) Angstrom, beta = 100.05(7)degrees, R = 0.047 for 1044 independent reflections. Heating cycloheptatriene and alkynes R'C = CR' (R' = SiMe(3), Me, Et) in dibutyl ether with a catalytic amount of Cr(CO)(6) or Fe-2(CO)(9) also gives good yields of the [6 + 2] cycloadducts 3, whereas the thermal reaction with dimethyl acetylenedicarboxylate in the presence of Cr(CO)(6) gives the known norcaradiene [4 + 2] adduct 9.
• Nucleophilic addition reactions of bridged triene η⁶-chromiumtricarbonyl complexes
  作者：Rohan E. J. Beckwith、Michael B. Gravestock、Nigel S. Simpkins

  DOI：10.1039/b207708f

  日期：——

  The metal-mediated addition of a range of nucleophiles to several bridged η6-chromiumtricarbonyl complexes has been demonstrated for the first time. The reaction proceeds in regio- and stereoselective fashion and in fair to good yield. The new reaction was applied to the synthesis of an advanced intermediate towards anatoxin-a.

  首次证明了金属介导的一系列亲核物与几种桥接δ-6-铬三羰基络合物的加成反应。该反应以区域和立体选择性方式进行，收率相当高。新反应被用于合成锐毒毒素-a 的高级中间体。