Pyrimido[1,6-a]azepine | 19565-76-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吖庚因类
• 英文名称: Pyrimido[1,6-a]azepine
• 英文别名: pyrimido[1,6-a]azepine
• CAS: 19565-76-5
• 化学式: C₉H₈N₂
• 分子量: 144.17
• InChiKey: LYCQBQASJFTYLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  15.6
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF
  申请人：SILVERBACK THERAPEUTICS, INC.

  公开号：US20210154188A1

  公开（公告）日：2021-05-27

  Compounds, conjugates and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds may be useful, among other things, in treating of cancer and inhibiting ALKS. Compounds incorporated into a conjugate with an antibody construct are also described herein.
• TGFßR1 INHIBITOR-ASGR ANTIBODY CONJUGATES AND USES THEREOF
  申请人：Silverback Therapeutics, Inc.

  公开号：US20210130473A1

  公开（公告）日：2021-05-06

  Various conjugates and compositions thereof are disclosed for use in the treatment of a liver disease, such as liver cancer and liver fibrosis. The compositions comprise conjugates, wherein the conjugates are comprised of an antibody or antibody construct specific for ASGR1 or ASGR2 attached to a TGFβR1 inhibitor via a linker. Additionally provided are the methods of preparation of the conjugates and compositions thereof.