2-[(3-bromophenyl)methyl]-6-(4-methylphenyl)-3H-thieno[2,3-d]pyrimidin-4-one | 1393911-80-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: 2-[(3-bromophenyl)methyl]-6-(4-methylphenyl)-3H-thieno[2,3-d]pyrimidin-4-one
• CAS: 1393911-80-2
• 化学式: C₂₀H₁₅BrN₂OS
• 分子量: 411.322
• InChiKey: VCIXWKPFAUBLEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  69.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-Amino-5-(4-methyl-phenyl)-thiophene-3-carboxylic Acid Amide 、 3-溴苯乙酸 在 1-丙基磷酸酐 、 三乙胺 作用下， 以 氯仿 为溶剂， 以97%的产率得到2-[(3-bromophenyl)methyl]-6-(4-methylphenyl)-3H-thieno[2,3-d]pyrimidin-4-one
  参考文献：
  名称：

  One-pot synthesis of thieno [2,3-d] pyrimidin-4-ol derivatives mediated by polyphosphonic anhydride

  摘要：

  An efficient synthesis of thiopyrimidines with different substituents in position 2 is described. A rapid, mild and high yielding microwave-assisted one-pot cyclization of 5-substituted 2-amino thiophene-3-carboxamide derived from Gewald reaction(1) with T3P and different acids gives the corresponding thiopyrimidines. The significant feature of this method includes less reaction time, high purity and reduced toxicity of the reaction. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.06.017

文献信息

• One-pot synthesis of thieno [2,3-d] pyrimidin-4-ol derivatives mediated by polyphosphonic anhydride
  作者：Subba Poojari、P. Parameswar Naik、G. Krishnamurthy

  DOI：10.1016/j.tetlet.2012.06.017

  日期：2012.8

  An efficient synthesis of thiopyrimidines with different substituents in position 2 is described. A rapid, mild and high yielding microwave-assisted one-pot cyclization of 5-substituted 2-amino thiophene-3-carboxamide derived from Gewald reaction(1) with T3P and different acids gives the corresponding thiopyrimidines. The significant feature of this method includes less reaction time, high purity and reduced toxicity of the reaction. (C) 2012 Elsevier Ltd. All rights reserved.