WZB-101 | 1223396-74-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: WZB-101
• 英文别名: [3-Fluoro-2-(3,4,5-trimethoxybenzoyl)oxyphenyl] 3,4,5-trimethoxybenzoate
• CAS: 1223396-74-4
• 化学式: C₂₆H₂₅FO₁₀
• 分子量: 516.477
• InChiKey: TZKAPSSDJLEREP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  37
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  108
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  3-氟邻苯二酚 、 3,4,5-三甲氧基苯甲酰氯 在 4-二甲氨基吡啶 作用下， 以 乙腈 为溶剂， 生成 WZB-101
  参考文献：
  名称：

  Novel inhibitors of basal glucose transport as potential anticancer agents

  摘要：

  Cancer cells commonly show increased levels of glucose uptake and dependence. A potential strategy for the treatment of cancer may be the inhibition of basal glucose transport. We report here the synthesis of a small library of polyphenolic esters that inhibit basal glucose transport in H1299 lung and other cancer cells. These basal glucose transport inhibitors also inhibit cancer cell growth in H1299 cells, and these two activities appear to be correlated. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.02.027

文献信息

• Novel inhibitors of basal glucose transport as potential anticancer agents
  作者：Weihe Zhang、Yi Liu、Xiaozhuo Chen、Stephen C. Bergmeier

  DOI：10.1016/j.bmcl.2010.02.027

  日期：2010.4

  Cancer cells commonly show increased levels of glucose uptake and dependence. A potential strategy for the treatment of cancer may be the inhibition of basal glucose transport. We report here the synthesis of a small library of polyphenolic esters that inhibit basal glucose transport in H1299 lung and other cancer cells. These basal glucose transport inhibitors also inhibit cancer cell growth in H1299 cells, and these two activities appear to be correlated. (C) 2010 Elsevier Ltd. All rights reserved.