(3aR,4R,6R,6aR)-2,2-dimethyl-4-(4-methylsulfanylthieno[3,4-d]pyrimidin-7-yl)-6-(oxan-2-yloxymethyl)-6,6a-dihydro-3aH-furo[3,4-d][1,3]dioxole-4-carbonitrile | 1238580-64-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: (3aR,4R,6R,6aR)-2,2-dimethyl-4-(4-methylsulfanylthieno[3,4-d]pyrimidin-7-yl)-6-(oxan-2-yloxymethyl)-6,6a-dihydro-3aH-furo[3,4-d][1,3]dioxole-4-carbonitrile
• CAS: 1238580-64-7
• 化学式: C₂₁H₂₅N₃O₅S₂
• 分子量: 463.579
• InChiKey: QIHZAIVGXMVZFA-VCRBHNENSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  149
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• [EN] CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT<br/>[FR] ANALOGUES DE CARBA-NUCLÉOSIDE POUR TRAITEMENT ANTIVIRAL
  申请人：GILEAD SCIENCES INC

  公开号：WO2010093608A1

  公开（公告）日：2010-08-19

  Provided are thieno[3,4-d]pyrimidin-7-yI and furo[3,4-d]pyrimidin-7-yl ribosides, riboside phosphates and prodrugs thereof as well as intermediates and methods of preparation. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections.

  提供了噻吩[3,4-d]嘧啶-7-基和呋喃[3,4-d]嘧啶-7-基核糖苷、核糖苷磷酸盐及其前药，以及其中间体和制备方法。所提供的化合物、组合物和方法对于治疗黄病毒科病毒感染是有用的。
• methods for the preparation of thieno[3,4-d]pyrimidin-7-yl ribosides
  申请人：GILEAD SCIENCES, INC.

  公开号：EP2719701A1

  公开（公告）日：2014-04-16

  The invention relates to intermediates and methods of preparing thieno[3,4-d]pyrimidin-7-yl and furo[3,4-d]pyrimidin-7-yl ribosides, riboside phosphates and prodrugs thereof which are useful for the treatment of flaviviridae infections. The intermediates are of formula V

  本发明涉及用于治疗黄病毒感染的噻吩并[3,4-d]嘧啶-7-基和呋喃并[3,4-d]嘧啶-7-基核糖苷、核糖苷磷酸盐及其原药的中间体和制备方法。 中间体为式 V
• Method for the preparation of thieno[3,4-d]pyrimidin-7-yl ribosides
  申请人：GILEAD SCIENCES, INC.

  公开号：EP2719701B1

  公开（公告）日：2017-04-05
• CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT
  申请人：Butler Thomas

  公开号：US20100203015A1

  公开（公告）日：2010-08-12

  Provided are thieno[3,4-d]pyrimidin-7-yl and furo[3,4-d]pyrimidin-7-yl ribosides, riboside phosphates and prodrugs thereof as well as intermediates and methods of preparation. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections.
• US8012942B2
  申请人：——

  公开号：US8012942B2

  公开（公告）日：2011-09-06