2,8a-dibromo-octahydro-naphthalen-1-one | 90944-72-2

• 分子结构分类: 有机化合物 - 有机磷化合物
• 英文名称: 2,8a-dibromo-octahydro-naphthalen-1-one
• 英文别名: 2,8a-Dibrom-octahydro-naphthalin-1-on；2.9-Dibrom-decal-1-on
• CAS: 90944-72-2
• 化学式: C₁₀H₁₄Br₂O
• 分子量: 310.029
• InChiKey: VEXZCDWJHPBLAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.44
• 重原子数：
  13.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  2,4,6-三甲基吡啶 、 2,8a-dibromo-octahydro-naphthalen-1-one 生成 四氢萘酚
  参考文献：
  名称：

  Diet and Exercise Habits of Patients with Diabetes, Dyslipidemia, Cardiovascular Disease or Hypertension

  摘要：

  Objective: The objective of this study was to determine whether free-living individuals diagnosed with diabetes, dyslipidemia, cardiovascular disease or hypertension follow standard dietary recommendations for treatment of these diet-modifiable disorders.Methods: Data are from 1,782 adult men and women who completed an annual clinic visit as part of a large study of diet and health. Usual dietary intake over the previous month was assessed with a self-administered food frequency questionnaire. Trained staff obtained a detailed medical history and information on health and exercise habits, measured height and weight, and collected a fasting blood specimen to measure total serum cholesterol, triglycerides and carotenoids. Multivariate, linear regression was used to test associations of diet-modifiable chronic diseases with diet and exercise habits.Results: 42% of the study sample reported at least one diet-modifiable disease or risk factor for disease. These individuals had higher total serum cholesterol (p < 0.001) and triglycerides p < 0.001) compared to those without these conditions. Diabetics consumed a greater percent of energy from fat (p < 0.01), and men with hypertension consumed a greater percent energy from saturated fat (p < 0.05) compared to those without these conditions. There were few other differences in dietary intake between diseased and healthy individuals. and on average, all participants had diets that were not consistent with recommended guidelines for prevention or treatment of these diet-modifiable disorders. Forty-six percent of all participants were overweight or obese, and BMI was significantly higher among participants with at least one diet-modifiable disorder (p < 0.001). Healthy and diseased participants exercised about 17 minutes per day, and compared to non-diabetics, persons with diabetes exercised with 25% less intensity (p < 0.05).Conclusion: Participants in this sample with diet-modifiable disorders reported that they are motivated to eat less fat, but most are still overweight or obese, consume a diet high in fat and low in fruits and vegetables and engage in very little physical exercise. New strategies are needed to help patients adopt and maintain healthful dietary practices that will reduce their risk.

  DOI：

  10.1080/07315724.2002.10719241
• 作为产物：
  描述：

  trans-1-decalone 在 氯仿 、 溴 作用下， 生成 2,8a-dibromo-octahydro-naphthalen-1-one
  参考文献：
  名称：

  Dietary Protein, Phosphorus and Potassium Are Beneficial to Bone Mineral Density in Adult Men Consuming Adequate Dietary Calcium

  摘要：

  Objective: The purpose of this study was to determine relationships of calcium (Ca), protein (Pr), phosphorus (P) and potassium (K) to measures of bone mineral density in adult men.Methods: Cross-sectional analysis of 57 men ages 39 to 42 years who were participants in an ongoing study. Dietary assessment was conducted using the Block food frequency questionnaire (FFQ). BMD of total body (TB), hip and lumbar spine (LS) were measured with dual X-ray absorptiometry (DXA).Results: Ca, Pr, P and K, as well as lean body mass (LBM), showed significant correlation with BMD at the total body, hip and lumbar spine. Stepwise forward regression selection method identified LBM. height and fat mass as significant predictors of TB-BMD, LBM and height as significant predictors of hip BMD, and LBM as a significant predictor of LS-BMD. As the nutrients tested correlated significantly with each other, only one nutrient was entered into the regression model at a time to accommodate the potential for multicollinearity. In regression analysis, adjusted for site-specific anthropometric variables and energy intake, K, Pr and P intake accounted for significant (p < 0.05) prediction of TB-BNID and LS-BMD values by 7% to 13%. No bone-related nutrient added significantly to the prediction of hip BMD. Ca intake was not significantly associated with BMD at any site in the adjusted models.Conclusions: Our analysis provides support that a moderate protein 0.2 g/kg) diet, plentiful in potassium (>100 mmol/day) and phosphorus (1741 +/- 535 mg) is beneficial for maintaining bone mineral density in adult men when Ca intake was adequate (1200 +/- 515 mg).

  DOI：

  10.1080/07315724.2002.10719242

文献信息

• The Stereochemistry of Ketonization. IX. The 1,9-Enol of 1-Decalone^1,2
  作者：Howard E. Zimmerman、Ago Mais

  DOI：10.1021/ja01523a039

  日期：1959.7