Catharanthin-saeure | 63944-54-7

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 依波格型生物碱
• 英文名称: Catharanthin-saeure
• 英文别名: 3,4-didehydro-ibogamine-18-carboxylic acid；Catharanthinic Acid；17-ethyl-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4,6,8,16-pentaene-1-carboxylic acid
• CAS: 63944-54-7
• 化学式: C₂₀H₂₂N₂O₂
• 分子量: 322.407
• InChiKey: QTHYWTOIDWEUIY-UHFFFAOYSA-N

物化性质

• 熔点：
  165-167°C (dec.)
• 沸点：
  545.3±50.0 °C(Predicted)
• 密度：
  1.35±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于DMF、DMSO、甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  56.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• ANTI-CANCER PHOSPHONATE ANALOGS
  申请人：Boojamra Constantine G.

  公开号：US20100022467A1

  公开（公告）日：2010-01-28

  The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及磷取代的抗癌化合物、含有这些化合物的组合物以及包括给予这些化合物的治疗方法，还涉及用于制备这些化合物的过程和中间体。
• 10'-FLUORINATED VINCA ALKALOIDS PROVIDE ENHANCED BIOLOGICAL ACTIVITY AGAINST MDR CANCER CELLS
  申请人：Boger Dale L.

  公开号：US20120329822A1

  公开（公告）日：2012-12-27

  A 10′-fluoro-vinca alkaloid compound or its pharmaceutically acceptable salt is disclosed, as are methods of its preparation and use. A disclosed 10′-fluoro-vinca alkaloid compound has better cytotoxic potency against leukemia and cancer cell lines, and is about 8-times more cytotoxic to a multiple drug resistant cancer cell line than is a parental 10′-unsubstituted vinca alkaloid.

  本发明揭示了10'-氟-长春碱化合物或其药学上可接受的盐，以及其制备和使用的方法。所揭示的10'-氟-长春碱化合物对白血病和癌细胞系具有更好的细胞毒性，对多药耐药癌细胞系的细胞毒性约为亲代10'-未取代长春碱的8倍。
• US7452901B2
  申请人：——

  公开号：US7452901B2

  公开（公告）日：2008-11-18
• US8940754B2
  申请人：——

  公开号：US8940754B2

  公开（公告）日：2015-01-27
• [EN] 10'-FLUORINATED VINCA ALKALOIDS PROVIDE ENHANCED BIOLOGICAL ACTIVITY AGAINST MDR CANCER CELLS<br/>[FR] VINCA-ALCALOÏDES 10'-FLUORÉS DOTÉS D'UNE ACTIVITÉ BIOLOGIQUE AUGMENTÉE CONTRE LES CELLULES CANCÉREUSES MULTIRÉSISTANTES
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2011103007A2

  公开（公告）日：2011-08-25

  A 10'-fluoro-vinca alkaloid compound or its pharmaceutically acceptable salt is disclosed, as are methods of its preparation and use. A disclosed 10'-fluoro-vinca alkaloid compound has better cytotoxic potency against leukemia and cancer cell lines, and is about 8-times more cytotoxic to a multiple drug resistant cancer cell line than is a parental 10'-unsubstituted vinca alkaloid.